Results 31 to 40 of about 83,742 (251)

Odd structures are odd

, 2016
By an odd structure we mean an algebraic structure in the category of graded vector spaces whose structure operations have odd degrees. Particularly important are odd modular operads which appear as Feynman transforms of modular operads and, as such ...
Markl, M.
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A simplified space vector modulation implementation for modular multilevel converter by grouping submodules

IET Power Electronics, 2021
Abstract Modulation strategy plays an important role in the good performance of modular multilevel converter (MMC). Since MMC has a special structure as well as a large number of submodules (SMs), it is almost impossible to apply the conventional multilevel space vector modulation (SVM) algorithm in it. In this study, a simplified SVM
Zhihong Bai, Haoqi Chen, Yifei Li, Yinuo Dong, Hao Ma   +4 more
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Space vector pulse width modulation strategy for modular multilevel converters in power system

IET Cyber-Physical Systems: Theory & Applications, 2023
Abstract As a superior modulation strategy, space vector pulse width modulation (SVPWM) provides redundant voltage vectors and adjustable action time, which can achieve multi‐objective control of modular multilevel converter (MMC). An SVPWM strategy suitable for MMC is proposed. The strategy is divided into three stages.
Shengyang Lu, Yan Zhenhong, Xiong Yongsheng, Zhang Jianhao, Wang Tong, Zhu Yu, Sui Yuqiu, Yang Junyou, Li Zhang, Haixin Wang   +9 more
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

On a new nonlinear convex structure

AIMS Mathematics
In this work we start from near vector spaces, which we endow with some additional properties that allow convex analysis. The seminormed structure used here will also be improved by adding properties such as the null condition and null equality, thus ...
Andreea Bejenaru, Mihai Postolache
doaj   +1 more source

Basic vector valued Siegel modular forms of genus two [PDF]

, 2015
We consider the space of all vector-valued holomorphic modular forms f:H_n→Z of transformation type f(MZ)=vr(M)det(CZ+D)ϱ(CZ+D)f(Z). ϱ:GL(n,C)→GL(Z) is a rational representation on a finite dimensional complex vector space Z.
Freitag, Eberhard, SALVATI MANNI, Riccardo   +1 more
core  

Loop Homotopy Algebras in Closed String Field Theory

, 1999
Barton Zwiebach constructed the `string products' on the Hilbert space of combined conformal field theory of matter and ghosts. It is well-known that the `tree level' specialization of these products forms a strongly homotopy Lie algebra.
Markl, Martin
core   +1 more source