Results 31 to 40 of about 420,182 (254)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Note on the Dual Codes of Module Skew Codes [PDF]

open access: yes, 2011
In [4], starting from an automorphism θ of a finite field ${\mathbb F}_q$ and a skew polynomial ring $R={\mathbb F}_q[X;\theta]$ , module θ -codes are defined as left R -submodules of R /Rf where f ∈R . In [4] it is conjectured that an Euclidean self-dual module θ -code is a θ -constacyclic code and a proof is given in the special ...
Boucher, Delphine, Ulmer, Félix
openaire   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Single-Carrier Modulation versus OFDM for Millimeter-Wave Wireless MIMO

open access: yes, 2017
This paper presents results on the achievable spectral efficiency and on the energy efficiency for a wireless multiple-input-multiple-output (MIMO) link operating at millimeter wave frequencies (mmWave) in a typical 5G scenario.
Buzzi, Stefano   +4 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

HARQ Buffer Management: An Information-Theoretic View

open access: yes, 2015
A key practical constraint on the design of Hybrid automatic repeat request (HARQ) schemes is the size of the on-chip buffer that is available at the receiver to store previously received packets. In fact, in modern wireless standards such as LTE and LTE-
Kang, Joonhyuk   +4 more
core   +1 more source

Nested turbo codes for the costa problem [PDF]

open access: yes, 2008
Driven by applications in data-hiding, MIMO broadcast channel coding, precoding for interference cancellation, and transmitter cooperation in wireless networks, Costa coding has lately become a very active research area.
Cheng, Samuel   +5 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

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