Results 231 to 240 of about 152,793 (295)

HPV-Driven Immune Evasion in Cervical Cancer: Transcriptomic Identification of Downregulated Hub Genes and Suppressed Leukocyte Migration Pathways. [PDF]

Int J Mol Sci
Ismael Ameen S, Masoudi M, Azizi H, Skutella T.   +3 more
europepmc   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Rationally Designed Dual Kinase Inhibitors for Management of Obstructive Sleep Apnea-A Computational Study. [PDF]

Biomedicines
Gramatikoff K, Stoykov M, Milkov M.
europepmc   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

xBitterT5: an explainable transformer-based framework with multimodal inputs for identifying bitter-taste peptides. [PDF]

J Cheminform
Nguyen NDH, Pham NT, Tran DT, Wei L, Malik A, Manavalan B.   +5 more
europepmc   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Selective modulation of orexinergic receptors by neem-derived phytochemicals: Computational analysis of structure-activity relationships. [PDF]

Toxicol Rep
Agboola OE, Agboola SS, Agboinghale PE, Ayinla ZA, Oyebamiji AK, Olaiya OE, Fajana OM, Oyinloye OM, Adewale AI, Idowu OT, Osunsanmi FO, Ajiboye BO, Oyinloye BE.   +12 more
europepmc   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Vehicle-to-Vehicle Secure Communication Protocol Based on Digital Vehicle Identification Number. [PDF]

Sensors (Basel)
Escapa Gordón P, Matellán Olivera V, Suárez Corona A.   +2 more
europepmc   +1 more source

Therapeutic target database 2026: facilitating targeted therapies and precision medicine. [PDF]

Nucleic Acids Res
Zhang Y, Zhou Y, Xu H, Jiang W, Li B, Lai D, Wan C, Wang S, Zhao M, Tan Y, Lu S, Fan T, Liu X, Zhu F, Chen Y.   +14 more
europepmc   +1 more source