Results 71 to 80 of about 5,478 (167)

Sequential induction of effector function, tissue migration and cell death during polyclonal activation of mouse regulatory T-cells [PDF]

, 2012
The ability of CD4+Foxp3+ regulatory T-cells (Treg) to produce interleukin (IL)-10 is important for the limitation of inflammation at environmental interfaces like colon or lung. Under steady state conditions, however, few Tregs produce IL-10 ex vivo. To
Gogishvili, Tea, Hünig, Thomas, Kneitz, Susanne, Langenhorst, Daniela, Lutz, Manfred B., McPherson, Kirsty, Ribechini, Eliana   +6 more
core   +4 more sources

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis [PDF]

, 2017
Megakaryocytopoiesis is a complex differentiation process driven by the hormone thrombopoietin by which haematopoietic progenitor cells give rise to megakaryocytes, the giant bone marrow cells that in turn break down to form blood platelets.
A Hart, AP Tsang, CA Graaf de, D Ord, E Bianchi, E Kiss-Toth, F Goncalves, G Wang, IS Hitchcock, J Boudeau, K Du, K Eto, L Pang, L Qi, L Roy, M Ahluwalia, M Ahluwalia, MC Chan, MC Rouyez, N Ohoka, O Bezy, RA Shivdasani, RA Shivdasani, S Fichelson, S Kato, S Severin, Y Hong, Y Takahashi, Z Hegedus   +28 more
core   +2 more sources

Transient Transfection of Rolling‐Circle Amplified DNA in Biomanufacturing‐Relevant Mammalian Cell Lines: A Comparison of Transfection Conditions for Optimal Protein Expression

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Rolling‐circle amplification (RCA) is a completely synthetic and rapid mechanism for scaling‐up bulk DNA that eliminates requirements for large‐scale bacterial fermentation. Several reports have described the surprising ability of large unprocessed (hyperbranched) rolling circle‐amplified DNA (RCA DNA) to effectively transfect cultured cells ...
Evelina Loghin, Erik Kvam, Lisa Lowery, Nathan Hudson, Jenny Keen, Brian Davis, Roger B. Dodd, Christine Surrette, John Nelson   +8 more
wiley   +1 more source

Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production [PDF]

, 2016
Sertoli cells, can function as non-professional tolerogenic antigen-presenting cells, and sustain the blood-testis barrier formed by their tight junctions.
A Beausejour, A Fettelschoss, A Jabeen, A Meinhardt, A Orvedahl, AD Polpitiya, AJ Schuerwegh, B Sun, C Conforti-Andreoni, DG Cyr, DH Kim, EM Creagh, F Martinon, F Martinon, F Martinon, F Martinon, F Martinon, FG Bauernfeind, G Burnstock, G Lemke, G Lopez-Castejon, G Metodieva, H Wu, HK Lee, IM Matalliotakis, J González-Benítez, J Harris, J Kummer, JP Ting, K Nakahira, KR Bortoluci, L Agostini, L Feldmeyer, L Qian, LH Travassos, M Keller, M Rassoulzadegan, MW Pfaffl, NP Chung, P Kankaanpaa, P Rosenstiel, PJ Sansonetti, PO Krutzik, PP Lie, R Cooney, S Bhushan, S Hayrabedyan, S Kimura, S Mariathasan, T Liu, T Saitoh, TD Kanneganti, V Dal Secco, Y Benjamini, Y Ogura, Y Takahashi, Y Xu, YG Kim, YG Kim   +58 more
core   +1 more source

The impacts of biological invasions

Biological Reviews, EarlyView.
ABSTRACT The Anthropocene is characterised by a continuous human‐mediated reshuffling of the distributions of species globally. Both intentional and unintentional introductions have resulted in numerous species being translocated beyond their native ranges, often leading to their establishment and subsequent spread – a process referred to as biological
Phillip J. Haubrock, Teun Everts, Neil Angelo S. Abreo, Jamie Bojko, Victor Deklerck, James W. E. Dickey, Ana Clara S. Franco, Emili García‐Berthou, Stelios Katsanevakis, Natalia I. Kirichenko, Stefano Mammola, Martin A. Nuñez, Ben Parker, Riccardo Scalera, Ismael Soto, Diederik Strubbe, Ali Serhan Tarkan, Lorenzo Vilizzi, Tim Adriaens, Paride Balzani, Dagmara Błońska, Elizabeta Briski, Rein Brys, Amy L. Burgess, James E. Byers, Carlos Cano‐Barbacil, Giuseppe Castaldelli, Jaimie T.A. Dick, Victoria Dominguez Almela, Romina D. Dimarco, Margarita Florencio, Antonín Kouba, Melina Kourantidou, Irmak Kurtul, Irene Martín‐Forés, Olivier Morissette, Julian D. Olden, Bruno E. Soares, Jakub Truszkowski, Hugo Verreycken, Marc Kenis, Ronaldo Sousa, J. Robert Britton   +42 more
wiley   +1 more source

Construction of a clickable probe‐based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts

iMeta, EarlyView.
In this study, we develop a flexible Ccc‐Chip (protein microarray + bioorthogonal click chemistry) for high‐throughput screening of natural covalent active molecules from medicinal plant extracts, identifying flavokawain C from Piper methysticum Forst as a novel covalent mIDH1 inhibitor.
Zhao Cui, Jiameng Li, Caifeng Li, Mo Sun, Wei Liu, Xuxia Cao, Shiwen Deng, Junxian Cao, Hongjun Yang, Peng Chen   +9 more
wiley   +1 more source

Deciphering the Heterogeneity of Pulmonary Macrophages in Response to Fine Particles

Small, EarlyView.
This study introduces a dual‐labeled gold nanoparticle model to capture particle–responsive cells via integrating fluorescence‐activated cell sorting and single‐cell RNA sequencing. Fourteen macrophage subsets are identified with response and function heterogeneity, among which AMs_3, AMs_7, and recMacs_4 subsets show stronger phagocytic activation ...
Qing'e Shan, Zheng Dong, Ning Li, Zijie Zhou, Jiayu Ren, Wei Liu, Feng Xu, Yu Qi, Juan Ma, Yi Liu, Shuping Zhang, Sijin Liu   +11 more
wiley   +1 more source

Joint Three-Task Optical Performance Monitoring with High Performance and Superior Generalizability Using a Meta-Learning-Based Convolutional Neural Network-Attention Algorithm and Amplitude-Differential Phase Histograms Across WDM Transmission Scenarios

Photonics
Nonlinear noise power (NLNP) estimation, optical signal-to-noise ratio (OSNR) monitoring, and modulation format identification (MFI) are crucial for optical performance monitoring (OPM) in future dynamic WDM optical networks.
Di Zhang, Junyao Shi, Yameng Cao, Yan Ling Xue   +3 more
doaj   +1 more source

The surface-associated exopolysaccharide of Bifidobacterium longum 35624 plays an essential role in dampening host proinflammatory responses and repressing local TH17 responses [PDF]

, 2018
The immune-modulating properties of certain bifidobacterial strains, such as Bifidobacterium longum subsp. longum 35624 (B. longum 35624), have been well described, although the strain-specific molecular characteristics associated with such immune ...
Akdis, Cezmi A., Altmann, Friedrich, Ferstl, Ruth, Frei, Remo, Gleinser, Marita, Grant, Ray, Groeger, David, Healy, Selena, Molloy, Evelyn, Moriarty, Thomas Fintan, O'Connell Motherway, Mary, O'Mahony, Liam, Plattner, Stephan, Rodriguez-Perez, Noelia, Roper, Jennifer, Schiavi, Elisa, van Sinderen, Douwe, Ziegler, Mario   +17 more
core   +1 more source