Results 41 to 50 of about 117,165 (263)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optimization Scheme for Modulation of Data Transmission Module in Endoscopic Capsule

Sensors
The endoscopic capsule is a miniaturized device used for medical diagnosis, which is less invasive compared to traditional gastrointestinal endoscopy and can reduce patient discomfort.
Meiyuan Miao, Chen Ye, Zhiping Xu, Laiding Zhao, Jiafeng Yao   +4 more
doaj   +1 more source

Joint and Accurate OSNR Estimation and Modulation Format Identification Scheme Using the Feature-Based ANN

IEEE Photonics Journal, 2019
A joint and accurate optical signal-to-noise ratio (OSNR) estimation and modulation formats identification (MFI) scheme based on the artificial neural network (ANN) is proposed and demonstrated via both simulation and the experiment system.
Qian Xiang, Yanfu Yang, Qun Zhang, Yong Yao   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A Deep Q-Network based optimized modulation scheme for Dual-Active-Bridge converter to reduce the RMS current

Energy Reports, 2020
In order to reduce the conduction losses of the Dual-Active-Bridge (DAB) converter, this paper proposes an optimized modulation scheme based on deep reinforcement learning (DRL).
Yuanhong Tang, Weihao Hu, Jian Xiao, Zhengdong Lu, Zhou Liu, Zhe Chen, Frede Blaabjerg   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A Multilevel Current-Fed DAB Converter With Direct Power Transfer

IEEE Open Journal of Power Electronics
This paper proposes a novel modulation scheme for a multilevel Dual Active Bridge (DAB) DC–DC converter with direct power transfer capability in PV applications.
Sajjad Goudarzitaemeh, Lucas Melanson, Justin Woelfle, Majid Pahlevani   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

LDPC-Coded Modulation Performance Analysis and System Design

IEEE Access, 2020
In this work, the low-density parity-check (LDPC)-coded modulation scheme which has been selected for inclusion in the next generation of International Telecommunication Union (ITU) broadband standard is investigated.
Cornelius Tomas Healy, Anas Al Rawi, Charalampos C. Tsimenidis   +2 more
doaj   +1 more source