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Modulation of oxidative stress as an anticancer strategy
Nature Reviews Drug Discovery, 2013The regulation of oxidative stress is an important factor in both tumour development and responses to anticancer therapies. Many signalling pathways that are linked to tumorigenesis can also regulate the metabolism of reactive oxygen species (ROS) through direct or indirect mechanisms.
Chiara, Gorrini +2 more
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Sphingolipid Modulation: A Strategy for Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry, 2012Sphingolipids are membrane lipids that play important roles in the regulation of cell functions and homeostasis. Alterations in their metabolism have been associated with several pathologies. For this reason, therapeutic strategies based on the design of small molecules to restore sphingolipid levels to their physiological condition have rapidly ...
Antonio, Delgado +4 more
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The Strategy and Method in Modulating Finger Regeneration
Regenerative Medicine, 2014The tip of the human finger can regenerate if the amputation is distal to the nail bed, usually in young children. Studies in regeneration of rodent digits have shown that regeneration occurs if the amputation is distal to the mid-third phalanx for certain ages.
Yohan, Choi +3 more
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Strategies for Precise Modulation of Protein Degradation
Accounts of Chemical ResearchConspectusTargeted protein degradation (TPD) technologies, exemplified by proteolysis-targeting chimeras (PROTACs), have revolutionized therapeutic strategies by facilitating the selective degradation of pathogenic proteins instead of simply inhibiting their functions. This degradation-based strategy offers significant advantages over traditional small-
Shipeng He +2 more
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Analyzing multichip module testing strategies
IEEE Design & Test of Computers, 1994Incorporating test and fault diagnosis as critical design requirements is necessary to achieve high-quality, cost-effective multichip systems. However, evaluating where and when to test, and deciding upon the best test method and level, take considerable study.
Magdy S. Abadir +4 more
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Modulation of adiponectin as a potential therapeutic strategy
Atherosclerosis, 2014Adiponectin is produced predominantly by adipocytes and plays an important role in metabolic and cardiovascular homeostasis through its insulin-sensitizing actions and anti-inflammatory and anti-atherogenic properties. Recently, it has been observed that lower levels of adiponectin can substantially increase the risk of developing type 2 diabetes ...
Soo, Lim +2 more
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Programmed Modulation Strategies
2009This chapter contains sections titled: Optimized Space Vector Modulation Harmonic Elimination PWM Performance Index for Optimality Optimum PWM Minimum-Loss PWM Summary This chapter contains sections titled: References ]]>
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Modulation of immune responses ? strategies for optimising vaccines
Expert Opinion on Biological Therapy, 2004Over decades, vaccination has considerably reduced the morbidity and mortality caused by infectious pathogens. Efficient vaccines conferring long-term protection have been developed despite a minimal understanding of the specific immunological mechanisms involved in this protection.
Alain R, Dumont +2 more
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A three-module strategy for edge detection
IEEE Transactions on Pattern Analysis and Machine Intelligence, 1988The first module is a parallel process computing local edge strength and direction, while the last module is sequential process following edges. The originality of the overall method resides in the intermediate module, which is seen as a generalization of the nonmaximum-deletion algorithm.
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Modulating speed-accuracy strategies in major depression
Journal of Psychiatric Research, 2015Depression is associated with deficits in cognitive flexibility. The role of general slowing in modulating more specific cognitive deficits is however unclear.We assessed how depression affects the capacity to strategically adapt behavior between harsh and prudent response modalities and how general and specific processes may contribute to performance ...
VALLESI, ALESSANDRA +3 more
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