Results 81 to 90 of about 9,256,063 (344)
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source
Drug Design Strategies for GPCR Allosteric Modulators [PDF]
, 2012 Abstract Terms such as “nondruggable GPCRs” describe a unique group of GPCRs having strong biological hypothesis validation, but for which medicinal chemistry efforts based on orthosteric ligands have failed to produce marketed drugs (or even clinical development candidates).
P Jeffrey, Conn +2 more
openaire +2 more sources
Targeted Strategies to Modulate Stem‐Cell‐Relevant Pathways [PDF]
Stem Cells International, 2016 Modulation of stem cell behavior is of significant interest to the biomedical community and could lead to novel therapeutic advances in treating disease. Achieving this goal requires specific strategies that manipulate the pathways regulating stem cell plasticity and behavior.
Jonathan W. Lowery +3 more
openaire +3 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Five-level selective harmonic elimination PWM strategies and multicarrier phase-shifted sinusoidal PWM: A comparison [PDF]
, 2005 The multicarrier phase-shifted sinusoidal pulse-width modulation (MPS-SPWM) technique is well-known for its important advantage of offering an increased overall bandwidth as the number of carriers multiplied with their equal frequency directly controls ...
Agelidis, V.G. +3 more
core +1 more source
Self-precharge in single-leg flying capacitor converters [PDF]
, 2009 Flying Capacitor (FC) multilevel pulse width modulated (PWM) converters are an attractive choice due to the natural voltage balance property. During start-up of the converter, care has to be taken that the power switches are not exposed to voltage ...
Melkebeek, Jan +2 more
core +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
IEEE AccessA novel SWISS rectifier based on single active bridge converter (SAB-SR) is proposed. The high-low-high-low (HLHL) voltage waveform modulation to realize soft-switching for the power switches and the hybrid frequency control scheme to achieve high power ...
Bo Zeng +4 more
doaj +1 more source
The Harmonic Characteristic of the Advanced Synchronous SVPWM Overmodulation Strategy
IEEE Access, 2019 The speed range of the rail transit traction system is very wide and mostly uses the hybrid pulse width modulation. The traditional hybrid pulse width modulation requires different types of modulation strategies to cooperate in switching, which ...
Jie Chen +4 more
doaj +1 more source