Results 221 to 230 of about 272,527 (318)

<i>Pseudomonas aeruginosa lasR</i> mutants resist phagocytosis and alter inflammatory cytokine production by cystic fibrosis macrophages. [PDF]

mSphere
Aridgides DS, Mellinger DL, Gwilt LL, Correia AR, Finger CE, Goddard J, Hampton TH, Mould DL, Hogan DA, Ashare A.   +9 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Challenges to Assessing the Prevalence of Cystic Fibrosis in the Caribbean. [PDF]

Pediatr Pulmonol
Rivera-Figueroa KL, Martin CL, Le CA, Rojas WJ, Oñate LC, Aller SG.   +5 more
europepmc   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Integrated Electro-Optic Frequency Combs: Physical Mechanisms, Device Architectures, Material Platforms and System Applications. [PDF]

Nanomaterials (Basel)
Zeng H, Hu Q, Zhang Y, Liu X, Zhuang Y, Wang Z, Wei X, Xu Z.   +7 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

From mechanistic modeling to AI-driven design: computational strategies for targeting the γ-secretase complex. [PDF]

Brief Bioinform
Das S, Rao Padubidri S, K V S, Shetty KS, Jena R, K R H, Dehury B, Pandurangan AP.   +7 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Clinical landscape of gut microbiota modulators in cardiovascular disease therapy: Current status and future perspectives. [PDF]

Int J Cardiol Cardiovasc Risk Prev
Xiang R, Tang Y, Cao B.
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source