Results 141 to 150 of about 684,019 (318)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
An evaluation of commercially prepared modules used in technology education [PDF]
, 1999 Plan BMany technology education departments are moving from the traditional method of instruction to a modular based type of instruction. There are many modules that are available for schools to implement and many vendors to choose from.
Brown, Andy R.
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Endo-permutation modules as sources of simple modules. [PDF]
, 2003 The source of a simple $kG$-module, for a finite $p$-solvable group $G$ and an algebraically closed field $k$ of prime characteristic $p$, is an endo-permutation module (see~\cite{Pu1} or~\cite{Th}). L.
Mazza, Nadia
core
On characteristic p Verma modules and subalgebras of the hyperalgebra
, 1994 Let G be a finite dimensional semisimple Lie algebra; we study the class of infinite dimensional representations of Gcalled characteristic p Verma modules.
Carstensen, Vivi. +3 more
core +1 more source
Customizing your NSSE Survey: Topical Modules and Consortia Participation [PDF]
, 2020 This pre-recorded webinar reviews the basics of customizing your NSSE participation with Topical Modules or consortium participation. An overview of the available Topical Modules and consortia for the 2021 NSSE administration is provided, along with ...
Miller, Angie
core
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source