Results 201 to 210 of about 684,019 (318)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Digital Therapeutic Content for Substance Use Disorder Treatment: Development and Evaluation Study. [PDF]

JMIR Form Res
Bormann NL, Kalata A, Arndt S, Oesterle TS.   +3 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

GSEA and the coexpression network approach identify novel pathway connections of molecular processes affected in Porto-sinusoidal vascular disease. [PDF]

PLoS One
Iyer A, Doornbos C, Evelo C, Kutmon M, Ehrhart F.   +4 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Comparative study between online and offline defect assessment methods for roll to roll flexible PV modules

Flexible PV modules are manufactured using roll to roll (R2R) technology. These modules require a flexible barrier material to prevent water vapor ingress. The basic methodology to produce such barriers is to combine oxide layer (e.g.
Muhamedsalih, Hussam, Elrawemi, Mohamed, Blunt, Liam, Fleming, Leigh, Martin, Haydn, Jiang, Xiang   +5 more
core  

Confidence in antimicrobial stewardship and infection prevention among French medical residents: a national cross-sectional survey. [PDF]

JAC Antimicrob Resist
Ait Azzi I, Allemang-Trivalle A, Mercier N, Barthelemy CE, Fournier S, Davido B.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Long Non-Coding RNAs Identified as Hub Genes by Weighted Gene Co-Expression Network Analysis in <i>Schistosoma mansoni</i> Following Incubation with <i>Bothrops</i> Snake Venoms. [PDF]

Int J Mol Sci
Zenga-Carrenho M, Fischer-Carvalho A, Taveira-Barbosa TC, Jardim Poli P, Guimarães-Oliveira V, Alencar Chaves AF, Serrano SMT, Tahira AC, Verjovski-Almeida S, Sena Amaral M.   +9 more
europepmc   +1 more source