Results 161 to 170 of about 361,214 (268)

TGFβ1 Activates Lnc‐APUE to Promote Tumor Metastasis via the Alu Element‐Driven STAU1‐Mediated Decay of CDH1 mRNA

Advanced Science, EarlyView.
We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li, Jia‐Hui Huang, Jin‐E Yang, Yi‐Hang Li, Juan‐Zhen Hong, Ting‐Ting Wang, Ying‐Lei Chi, Meng‐Zhi Wu, Wei Wang, Ying Zhu, Shi‐Mei Zhuang   +10 more
wiley   +1 more source

Efficient and specific DNA-targeting using single-stranded LNA/MOE mixmers and chimeric Invader:XenoRNA probes.

Org Biomol Chem
Everly ME, Hrdlicka PJ.
europepmc   +1 more source

Synergistic effects and optimization of palm oil fuel ash and jute fiber in sustainable concrete. [PDF]

Sci Rep
Umer M, Zada NS, Awoyera PO, Khan MB, Ahmed W, Fadugba OG.   +5 more
europepmc   +1 more source

Altijd moe

FES magazine
Heb je ooit duidelijk en herhaald verteld aan anderen dat je altijd moe bent? Waarschijnlijk ben je er dan snel weer mee bent gestopt, omdat je niet als een klager wil overkomen. Het is echter ook geen goede keuze om helemaal niets over je vermoeidheid te zeggen. De mensen weten dan immers niet waarom je tempo zo laag ligt.
openaire   +1 more source

Enhanced Oxygen Redox Activity and Structure Stability of P2‐Type Manganese‐Based Cathodes Through Medium‐Entropy Strategy

Advanced Science, EarlyView.
A medium‐entropy strategy guided by ionic potential is applied to weaken TM─O bonds and suppress Jahn–Teller distortion in P2‐type cathodes, thereby enhancing the oxygen redox activity and structure stability. A medium‐entropy oxide, Na0.8Li0.1Ni0.1Cu0.1Ti0.1Mn0.6O2, demonstrates a high reversible capacity of 223.7 mAh g−1 and an energy density of 616 ...
Dongxiao Wang, Yuxuan Liu, Zihao Wang, Wei Su, Xingguo Qi, Huican Mao, Kan Zhang, Shigang Lu, Bingkun Guo, Yingchun Lyu   +9 more
wiley   +1 more source

CsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis

Advanced Science, EarlyView.
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin   +14 more
wiley   +1 more source

Enzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors. [PDF]

Nat Commun
Meng Q, Benckendorff C, Morrill C, Zhuo Y, Egerström A, Ní Cheallaigh A, Derrington SR, Obexer R, Ortmayer M, Levy CW, Finnigan JD, Charnock SJ, Turner NJ, Miller GJ, Lovelock SL.   +14 more
europepmc   +1 more source

Parasitic Plant–Host Interactions: Molecular Mechanisms and Agricultural Resistance Strategies

Advanced Science, EarlyView.
Parasitic plants devastate global agriculture through sophisticated molecular interactions with host crops. This review synthesizes current understanding of parasitic plant‐host interactions, from strigolactone‐mediated germination and haustorium formation to host defense mechanisms.
Jiayang Shi, Qi Xie, Feifei Yu
wiley   +1 more source

Identification and functional validation of intracellular protein partners of phosphorothioate splice-switching oligonucleotides using AP-MS. [PDF]

Mol Ther Nucleic Acids
Gaci A, Menchon G, Bruce J, Salnot V, Pedeux R, Goyenvalle A.   +5 more
europepmc   +1 more source

Ligand‐Induced Electronic Response Enables Predictive QM/MM Simulations

Advanced Science, EarlyView.
Quantum mechanics/molecular mechanics (QM/MM) simulations are powerful tools for modeling complex molecular systems; however, their predictability has been constrained by the ambiguous definition of the QM region. An electronically informed protocol is introduced that defines QM regions by quantifying guest‐induced orbital shifts and charge ...
Nichika Ozawa, Nahoko Kuroki, Hirotoshi Mori   +2 more
wiley   +1 more source