Results 191 to 200 of about 137,288 (297)

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

Leakage-Controlled and Information-Bounded Evaluation of Multi-Task Learning for Crumb-Rubber Modified Asphalt: What Twenty Mix Designs Can and Cannot Support. [PDF]

Materials (Basel)
Huang H, Gao Y, Tian B, Yang Z.
europepmc   +1 more source

Hlaing, Moe Moe

, 2020
Hlaing, Moe Moe
core  

Thermal‐Ionic Coupling in Transpiration‐Inspired Janus Nanofiber Membranes: Synergistic Dry‐Wet Interface Engineering for Solar‐Driven Electricity Generation

Advanced Science, EarlyView.
A transpiration‐inspired Janus nanofiber membrane creates a persistent dry‐wet interface that couples localized solar heating with hydration‐induced ion regulation. The asymmetric architecture sustains directional water and ion transport, suppresses salt accumulation, and enables simultaneous seawater evaporation and stable electricity generation ...
Qin Su, Haidi Wu, Tingting Zheng, Di He, Huaiguo Xue, Longcheng Tang, Yongqian Shi, Xuejun Lai, Jiefeng Gao, Wancheng Gu, Jun Yan   +10 more
wiley   +1 more source

Risk Assessment Models for Heated Tobacco Products. [PDF]

Risk Anal
Maddalena L, Yildiz B, Blanco FDV, Guarracino MR.   +3 more
europepmc   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

To scramble or not: Steric blocking 2'-MOE/PS control antisense oligonucleotides across cellular models. [PDF]

Mol Ther Nucleic Acids
De Bruycker E, Bouckaert M, Van Acker K, Delanote E, Meuris L, González-Cid Á, Lenaerts H, Denolf L, Remaut K, Staes A, Gevaert K, Lefever S, Coppieters F.   +12 more
europepmc   +1 more source

Entropy‐Driven Physical Amplification in Multivalent Biosensing

Advanced Science, EarlyView.
Detecting scarce molecules usually demands enzymatic amplification such as PCR. A statistical‐mechanical theory now reveals a purely physical alternative: distributing a fixed binding strength over more linker arms exponentially lowers the concentration at which multivalent sensors switch on.
Yuhan Peng, Xiuyang Xia, Ran Ni
wiley   +1 more source

Apocrine Hidrocystoma of the Lower Eyelid: A Case Report. [PDF]

Cureus
Wada M, Nagata I, Matsumoto A, Mitsui T, Kakudo N.   +4 more
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source