Results 161 to 170 of about 561,058 (359)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

¿Las Mejores Relaciones de Intercambio Ayudan a Reducir la Pobreza en África? [PDF]

open access: yes
¿Las Mejores Relaciones de Intercambio Ayudan a Reducir la Pobreza en África?
Andrew Mold
core  

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Impressora de Moldes - Sinterização Molde

open access: yes, 2017
O processo de fundição consiste num conjunto de etapas necessárias para moldar certos materiais ou ligas. Na primeira etapa recorre-se à fusão do material, seguindo-se o seu escoamento ou vazamento para moldes adequados e posterior solidificação. A Metalurgia tornou-se um dos sectores mais importantes da economia mundial por isso urgia aperfeiçoar ...
openaire   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

BATA LEMPUNG BAHAN BANGUNAN DINDING ALTERNATIF

open access: yesDimensi: Journal of Architecture and Built Environment, 2001
"Bata lempung" is block of wall material, main basic material is sols contains 50-60% clay, pressed and molded, without combusted, used after 28 days and production doesn't depend climates. "Bata lempung" can used as bearing wall or curtain wall, exposed
Vincentius Totok Noerwasito
doaj  

First Report of Botrytis cinerea Causing Gray Mold on Cardamine violifolia in China [PDF]

open access: bronze
Lin Li   +6 more
openalex   +1 more source

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