Results 281 to 290 of about 561,058 (359)

Development and Mechanical Characterization of a Jute Fiber-Reinforced Polyester Composite Helmet Produced by Vacuum Infusion. [PDF]

Polymers (Basel)
Cardoso RLB, Ribeiro MM, Silva DS, Junio RFP, Leão Filha EM, Monteiro SN, Rodrigues JDS.   +6 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Ultrafast Laser Shock Straining in Chiral Chain 2D Materials: Mold Topology-Controlled Anisotropic Deformation. [PDF]

Nanomicro Lett
Liu X, de Camargo Branco D, An L, Wang M, Jiang H, Wang R, Wu W, Cheng GJ.   +7 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Microbial Landscape of Pharmaceutical Failures: A 21-Year Review of FDA Enforcement Reports. [PDF]

BioTech (Basel)
Jimenez L.
europepmc   +1 more source

Potential of biocontrol agents for the management of castor grey mold, Botrytis ricini Godfrey

, 2003
M. A. Raoof, M Yasmeen, Rana Kausar
openalex   +1 more source

NRF2 Activation Suppressed Methylglyoxal-Lysine Dimer-Induced Oxidative Stress and Inflammatory Paracrine Interaction between Macrophages and Adipocytes. [PDF]

Prev Nutr Food Sci
Lee HW, Gu MJ, Kim D, Ha SK.
europepmc   +1 more source

Invasive Infection With Purpureocillium lilacinum: A Case of Fungal Peritonitis. [PDF]

Cureus
West JM, Whitaker L, Grubbs J, Samra H.
europepmc   +1 more source