Results 91 to 100 of about 360,152 (355)
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
, 2020 The risk of poor post-operative outcome and the benefits of surgical resection as a curative therapy require careful assessment by the clinical care team for patients with primary and secondary liver cancer.
Mole, Damian
core +1 more source
Metabolic and Microvascular Risk Factors Associated With Brain Health in Type 1 Diabetes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We examined relationships between metabolic factors, microvascular complications, and brain health in adults with type 1 diabetes. Fifty‐one adults were assessed for metabolic risk factors, microvascular complications, and cognitive function, with a subset completing brain MRI.
Jihyun Park +7 more
wiley +1 more source
[Postcard from Mr. William Mole, April 25, 1918]
, 1918 Postcard sent from Mr. William Mole to Maurice and Minnie picturing marching soldiers in Camp MacArthur in Waco, Texas, handwritten message in the back about the storm in his area and a letter that he had been working ...
Mole, William
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Letter from George Mole to James B. Finley [PDF]
Mole says Finley is unknown to him except through the press and reports. He has a little boy who he intends to name James B. Finley. He asks Finley to send his full name.
Mole, George
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Interview with Stuart Mole: Commonwealth Oral History Project [PDF]
Interview with Stuart Mole, conducted 1 February, 2013 (part 1) and 14 February 2014 (part 2) as part of the Commonwealth Oral History Project. The project aims to produce a unique digital research resource on the oral history of the Commonwealth since ...
Onslow, Sue, Mole, Stuart, Craggs, Ruth
core +3 more sources
Arthritis Care &Research, Accepted Article.Objectives To assess the validity of the Patient‐Reported Outcomes Measurement Information System® (PROMIS®) Pediatric measures in patients with chronic nonbacterial osteomyelitis (CNO). Methods Within the longitudinal patient registry of CNO, English‐speaking patients aged 8 years and older self‐reported PROMIS Pediatric measures of fatigue, pain ...
Mary M. Eckert +43 more
wiley +1 more source