Results 1 to 10 of about 4,938,802 (269)

Reconstruction of molecular vibrational spectra from light-molecular vibration coupling spectra using deep learning. [PDF]

Anal Sci
Nishijima Y, Imai S, Maeda H.
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

EXPRESSION OF CONCERN: An Upstream Open Reading Frame Regulates Vasculogenic Mimicry of Glioma via ZNRD1-AS1/miR-499a-5p/ELF1/EMI1 Pathway. [PDF]

J Cell Mol Med
europepmc   +1 more source

Clinical actionability of molecular testing in advanced thyroid cancer: a real-world cohort study. [PDF]

Eur Thyroid J
Changoer P, van Houten P, Ceruti D, van Engen-van Grunsven I, Walraven JEW, Ottevanger PB, Jaeger M, Netea-Maier RT.   +7 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Beyond target engagement: RNA therapeutics and the neuroimmune challenge in tauopathies. [PDF]

J Prev Alzheimers Dis
Breen EA.
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Tuning the acoustic and thermal insulation properties of polyimide aerogels <i>via</i> molecular rigidity and solid content synergy. [PDF]

RSC Adv
Wang Z, Qian G, Wang H, Li D, Li H.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

High Mammographic Density in Younger Women and Its Implications for Breast Cancer Subtypes. [PDF]

Int J Breast Cancer
Hikmawati S, Kardinah, Putri RI, Laiman V, Mupangat I, Irfan RM, Noor ZA, Laskarsantri PN, Safitri LS, Wahyono A, Heriyanto DS, Choridah L.   +11 more
europepmc   +1 more source