Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Effects of "On-Water" on the Free Radical Polymerization of Methacrylates. [PDF]
Kambe Y, Matsuoka SI.
europepmc +1 more source
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Intrinsic elaboration of prefrontal modularity: a dual-control model of axon bundling and synaptic docking. [PDF]
Yamamori T, Watakabe A, Skibbe H.
europepmc +1 more source
From Genes to Imaging Phenotypes: Radiomics and Machine Learning as Tools to Decode Molecular Pathways in Alzheimer's Disease. [PDF]
Rusek M, Pitucha M.
europepmc +1 more source
Integrating Megabarcoding and Metabarcoding to Unlock Diversity and Distribution Data Shortfalls in Dark Taxa. [PDF]
Santos-Perdomo I +12 more
europepmc +1 more source
Advancing clinical precision medicine via peripheral blood immune single-cell omics. [PDF]
Li L +5 more
europepmc +1 more source
Longitudinal methylated ctDNA increases predict immunotherapy progression across solid tumors. [PDF]
Anees M +17 more
europepmc +1 more source
Serine Octamer Substitution Reactions With α-Hydroxy Acids. [PDF]
Unni K +4 more
europepmc +1 more source

