Results 251 to 260 of about 15,058,672 (343)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Insights Into Bifenthrin Stereoisomers and Their Regulatory Implications. [PDF]

ChemistryOpen
Santos NCM, Coutinho ND, Duarte VS, Catao A, Aguiar ASN, Dias LD, Fajemiroye JO, Napolitano HB.   +7 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Neurotoxicity Prediction of Compounds: Integrating Knowledge-Guided Graph Representations with Machine Learning Approaches. [PDF]

Int J Mol Sci
Jiang Y, Gao Y, He Y, Xing S, Han W.
europepmc   +1 more source

Analysis of Influencing Factors in Quantum Chemistry Simulation Based on VQE Algorithm. [PDF]

Entropy (Basel)
Zhang M, Kang J, Wu Q, Han B.
europepmc   +1 more source

Synthesis, X-Ray Analysis, Anticancer Activity, Computational, and in Silico Studies of New Thiophene Pyrazole Conjugates. [PDF]

ChemistryOpen
Muhsinah AB, Kheder NA, Elhaty IA, Mabkhot YN.   +3 more
europepmc   +1 more source

Lipidated peptides and the limits of chemical control. [PDF]

Front Chem
Roque-Borda CA, Sharma A, Pavan FR, de la Torre BG, Albericio F.   +4 more
europepmc   +1 more source

Expression of Concern: Caveolin-1 Is Required for Contractile Phenotype Expression by Airway Smooth Muscle Cells. [PDF]

J Cell Mol Med
europepmc   +1 more source