Results 201 to 210 of about 3,910,941 (317)

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Histotripsy-Induced Bactericidal Activity Correlates to Size of Cavitation Cloud In Vitro. [PDF]

IEEE Trans Ultrason Ferroelectr Freq Control
Ambekar PA, Wang YN, Khokhlova TD, Thomas GPL, Rosnitskiy PB, Contreras K, Leotta DF, Maxwell AD, Bruce M, Pierson S, Totten S, Kumar YN, Thiel J, Chan K, Liles WC, Dellinger EP, Adedipe A, Monsky WL, Matula TJ.   +18 more
europepmc   +1 more source

Data‐Driven Feedback Identifies Focused Ultrasound Exposure Regimens for Improved Nanotheranostic Targeting of the Brain

Advanced Science, EarlyView.
ABSTRACT The blood‐brain barrier (BBB) renders the delivery of nanomedicine in the brain ineffective and the detection of circulating disease‐related DNA from the brain unreliable. Here, we demonstrate that microbubble‐enhanced focused ultrasound (MB‐FUS) mediated BBB opening, supported by large‐data models predict sonication regimens for safe and ...
Hohyun Lee, Victor Menezes, Shiqin Zeng, Chulyong Kim, Cynthia M. Baseman, Jae Hyun Kim, Samhita Padmanabhan, Pranav Premdas, Naima Djeddar, Anton Bryksin, Nikhil Pandey, Pavlos Anastasiadis, Anthony J. Kim, Tobey J. MacDonald, Chetan Bettegowda, Graeme F. Woodworth, Felix J. Herrmann, Costas Arvanitis   +17 more
wiley   +1 more source

Photoacoustic detection of propofol in breath gas for monitoring depth of anaesthesia: from bench to bedside. [PDF]

Br J Anaesth
Meidert AS, Rucz P, Angster J, Esser J, Miklós A, Schelling G.   +5 more
europepmc   +1 more source

3D‐MOF‐Lattice Inspired Programmable Metamaterials Based on Reconfigurable Polyhedral Origami

Advanced Science, EarlyView.
A novel metamaterial design strategy: inspired by MOFs crystal networks, creating reconfigurable modular polyhedral units to overcome the limitations of traditional materials. These modules exhibit adjustable stiffness, bistability, and Poisson's ratio that can be adjusted from negative to positive values.
Xi Kang, Yangqin Zhang, Hongshuang Fan, Ziyan Xu, Yue Dong, Bing Li   +5 more
wiley   +1 more source

Ultrasound cavitation modulates intracellular ROS and gene expression in antibacterial sonodynamic therapy. [PDF]

Ultrason Sonochem
Li X, Teng F, Wu F, Li C, Zhang H, Zhang C, Zhang D.   +6 more
europepmc   +1 more source

Tables of Physical and Chemical Constants

, 2018
G. Kaye, T. H. Laby
semanticscholar   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Acoustofluidics-Based Intracellular Nanoparticle Delivery. [PDF]

Engineering (Beijing)
Li Z, Tian Z, Belling JN, Rich JT, Zhu H, Ma Z, Bachman H, Shen L, Liang Y, Qi X, Heidenreich LK, Gong Y, Yang S, Zhang W, Zhang P, Fu Y, Ying Y, Jonas SJ, Li Y, Weiss PS, Huang TJ.   +20 more
europepmc   +1 more source

Ultrafine Ru‐M Alloy@S Vacancy‐Rich MoS2 Nanosheets With Bimetallic Active Sites for Efficient Hydrogen Evolution in Alkaline and Acidic Media

Advanced Science, EarlyView.
A USMR synthesizes ultrafine RuCo alloy on S‐vacancy‐rich 1T phase MoS2. This method enables rapid precursor mixing, instantaneous reduction, and uniform alloy dispersion while creating S vacancies. The synergy between Ru‐Co sites and defective MoS2 optimizes hydrogen kinetics, achieving a low overpotential of 31 mV@10 mA·cm‐2 in acid, providing a ...
Rui Su, Tiantian Ding, Hao Tang, Xueying Yang, Jie Zhang, Xiaolin Liu, Jinfu Jia, Yuan Liu, Jin Ge, Zhilin Wu, Zhengya Dong, Xiaojing Zhu   +11 more
wiley   +1 more source