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Molecular and Genetic Analyses at the CF Locus
1991Cystic fibrosis (CF) is the most frequent lethal autosomal recessive disorder of Caucasian populations. The disease incidence is commonly quoted as 1 in 2500 (Boat et al., 1989), but varies widely in different populations. Frequencies as low as 1:90,000 exist (Wright and Morton, 1968), and as high as 1:377 in Brittany (Bois et al., 1978), 1:313 in the ...
K W, Klinger +3 more
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Genetic and molecular analyses of motoneuron development
Current Opinion in Neurobiology, 1998Motoneurons have distinct identities and muscle targets. Recent classical and molecular genetic studies in flies and vertebrates have begun to elucidate how motoneuron identities and target specificities are established. Many of the same molecules participate in the guidance of both vertebrate and fly motor axons. It is less clear, however, whether the
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Phenotypic and Molecular Analyses of A/WySn Mice
The Cleft Palate Craniofacial Journal, 2001Objective: Since its first description, the A strain of mice have been utilized extensively as models to study the processes involved in clefting of the midfacial region. Of the A substrains, the A/WySn has a spontaneous rate of clefting of the lip of about 20% to 30%. The A/WySn mouse model was utilized in this
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Troubleshooting Molecular Phylogenetic Analyses
Annual Review of Ecology and Systematics, 2002▪ Abstract  The number, size, and scope of phylogenetic analyses using molecular data has increased steadily in recent years. This has simultaneously led to a dramatic improvement in our understanding of phylogenetic relationships and a better appreciation for an array of methodological problems that continue to hinder progress in phylogenetic studies ...
Michael J. Sanderson, H. Bradley Shaffer
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Representing and Analysing Molecular and Cellular Function Using the Computer
Biological Chemistry, 2000Determining the biological function of a myriad of genes, and understanding how they interact to yield a living cell, is the major challenge of the post genome-sequencing era. The complexity of biological systems is such that this cannot be envisaged without the help of powerful computer systems capable of representing and analysing the intricate ...
van Helden, Jacques +6 more
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Cytogenetic and molecular cytogenetic analyses in diffuse astrocytomas
Cancer Genetics and Cytogenetics, 2004Diffuse astrocytomas are highly variable tumors and show complex biologic behavior that is based on multi-step oncogenesis. We report cytogenetic and molecular cytogenetic investigations in 23 cases of diffuse astrocytomas. The results of conventional karyotyping, interphase fluorescence in situ hybridization (FISH), comparative genomic hybridization ...
Wolfgang, Krupp +4 more
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Signal, Noise, and Reliability in Molecular Phylogenetic Analyses
Journal of Heredity, 1992DNA sequences and other molecular data compared among organisms may contain phylogenetic signal, or they may be randomized with respect to phylogenetic history. Some method is needed to distinguish phylogenetic signal from random noise to avoid analysis of data that have been randomized with respect to the historical relationships of the taxa being ...
D M, Hillis, J P, Huelsenbeck
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Molecular analyses of microbial mats
2018Whether found in shallow water sediments or at the bottom of the deep-sea, microbial mats are key participants in the recycling and utilization of important elements and compounds. Despite these mats being nearly ubiquitous, little research has focused on the early stages of their community assemblage.
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Molecular analyses of in situ breast cancer
European Journal of Cancer Prevention, 1993M R, Stratton +3 more
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Molecular Imaging in Oncology: Current Impact and Future Directions
Ca-A Cancer Journal for Clinicians, 2022Martin G. Pomper, Steven P Rowe
exaly