Results 71 to 80 of about 3,939,990 (297)

A Hylarana latouchii Skin Secretion-Derived Novel Bombesin-Related Pentadecapeptide (Ranatensin-HLa) Evoke Myotropic Effects on the in vitro Rat Smooth Muscles

Toxins, 2019
Amphibians have developed successful defensive strategies for combating predators and invasive microorganisms encountered in their broad range of environments, which involve secretion of complex cocktails of noxious, toxic and diverse bioactive molecules
Yan Lin, Nan Hu, Haoyang He, Chengbang Ma, Mei Zhou, Lei Wang, Tianbao Chen   +6 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Human Cloning Public Policy Issues. National Academy of Sciences Forum (2001 August 7) (Part 3)

, 2001
"Professors talked about the ethics of human cloning for both therapeutic and reproductive reasons. Among the topics they addressed were methods of cloning, potential dangers involved, and potential benefits of cloning.
Producer: National Cable Satellite Corporation
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CLONING

, 2006
Foreword -- Introduction -- Ch. 1. Should reproductive cloning be pursued? -- 1. Reproductive cloning is ethical / Gregory E. Pence -- 2. Reproductive cloning is unethical / Peter J. Cataldo -- 3.
Gerdes, Louise, ed.
core   +2 more sources

Cel1, Probably Encoding a Cellobiohydrolase Lacking the Substrate Binding Domain, Is Expressed in the Initial Infection Phase of Claviceps purpurea on Secale cereale

Molecular Plant-Microbe Interactions, 1997
At the host-pathogen interface of hyphae penetrating host cell walls in the rye ovary, a lack of cellulase-gold labeling of β-1,4-glucan in host cell walls indicates that enzymatic degradation of cellulose might be an important factor during the ...
Ulrike Müller, Klaus B. Tenberge, Birgitt Oeser, Paul Tudzynski   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Human Reproductive Cloning. National Academy of Sciences Forum (2001 August 7) (Part 2)

, 2001
"In sometimes heated exchanges, a panel of experts [NAS Public Panel on Human Reproductive Cloning] questioned scientists about their plans to begin human cloning research. Among the issues addressed were ethical concerns, the safety of cloning research,
Producer: National Cable Satellite Corporation. C-SPAN
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Animal and Human Cloning Data. National Academy of Sciences Forum (2001 August 7) (Part 5)

, 2001
"Dr. Wilmut discussed the applicabilty of animal cloning data to human cloning. He was the scientist who cloned the sheep "Dolly" in Scotland. Dr. Van Steirteghem reviewed assisted reproductive technology in humans. Dr.
Producer: National Cable Satellite Corporation
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