Results 201 to 210 of about 22,673 (314)

Abiotic formation of nitrile precursors to amino acids and nucleobases in interstellar ice analogues. [PDF]

Chem Sci
Wang J, Inada S, Zhang C, Marks JH, Wang Z, Bergantini A, McAnally M, Eckhardt AK, Kaiser RI.   +8 more
europepmc   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

Inadequate turbulent support in low-metallicity molecular clouds [PDF]

Lingrui Lin, Zhi-Yu Zhang, Junzhi Wang, Panagiotis Papadopoulos, Yong Shi, Y. Gong, Yan Sun, Yichen Sun, Thomas G. Bisbas, D. Romano, Di Li, Hauyu Baobab Liu, Keping Qiu, Lijie Liu, Gan Luo, Chao‐Wei Tsai, Jingwen Wu, Siyi Feng, Bo Zhang   +18 more
openalex   +1 more source

Formation of amino acid precursors with large molecular weight in dense clouds and their relevance to origins of bio-homochirality [PDF]

, 2008
Kensei Kobayashi, Takeo Kaneko, Yoshinori Takano, Jun-ichi Takahashi   +3 more
openalex   +1 more source

Large-amplitude variability driven by giant dust storms on a planetary-mass companion. [PDF]

Sci Adv
Tan X, Zhang X, Marley MS, Zhou Y, Lew BWP, Miles BE, Batalha NE, Biller BA, Chauvin G, Hinkley S, Hoch KKW, Manjavacas E, Metchev S, Petrus S, Rickman E, Skemer A, Suárez G, Sutlieff BJ, Vos JM, Whiteford N.   +19 more
europepmc   +1 more source

Functional, Pharmacogenomic, and Immune Landscapes of Long Non‐Coding RNAs in Cancer

Advanced Science, EarlyView.
A systematic analysis of 33 cancer types reveals widespread associations between lncRNAs and cancer pathways, drug responses, immune features, and immunotherapy outcomes. The study identifies key lncRNAs linked to therapeutic response and adverse events and introduces PILNC, an interactive web portal for exploring the functional, pharmacogenomic, and ...
Runhao Wang, Mei Luo, Yuan Liu, Jingwen Yang, Yamei Chen, Chengxuan Chen, Lifei Ma, Stephanie Ding, James Wengler, Yong Zang, Bora Lim, Wenbo Li, Liuqing Yang, Chunru Lin, Lixia Diao, Leng Han   +15 more
wiley   +1 more source

Labeled dataset of X-ray protein ligand images in 3D point cloud and validated deep learning models. [PDF]

Sci Data
Bazzano CF, Alves LFG, Telles GP, Trivella DBB.   +3 more
europepmc   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

The Gould’s Belt Distances Survey (GOBELINS). V. Distances and Kinematics of the Perseus Molecular Cloud [PDF]

, 2018
Gisela N. Ortiz-León, Laurent Loinard, Sergio A. Dzib, P. A. B. Galli, Marina Kounkel, A. J. Mioduszewski, Luis F. Rodrı́guez, Rosa M. Torres, Lee Hartmann, Andrew F. Boden, Neal J. Evans, César Briceño, John Tobin   +12 more
openalex   +1 more source

Enhanced spatial clustering of single-molecule localizations with graph neural networks. [PDF]

Nat Commun
Pineda J, Masó-Orriols S, Masoliver M, Bertran J, Goksör M, Volpe G, Manzo C.   +6 more
europepmc   +1 more source