Results 121 to 130 of about 4,091,521 (342)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Computational study on 3D structure of L-aspartic acid and L-glutamic acid: molecular descriptors and properties [PDF]

, 2016
Amalia Ștefaniu, Valeria Gabriela Savoiu, Irina Lupescu, Olga Iulian   +3 more
openalex   +1 more source

Logistic regression and random forest unveil key molecular descriptors of druglikeness

, 2021
Liza T. Billones, Nadia B. Morales, Junie B. Billones   +2 more
openalex   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Development of Ensemble Steric and Electrostatic Chirality (ESEC) descriptors for modelling chromatographic enantioseparations.

PLoS ONE
In this work, chiral molecular descriptors were defined using 2 distinct approaches: (1) scalar triple products of vectorial molecular properties, and (2) descriptors that attempt to quantify the amount of twist in the overall molecular shape.
Jordy Peeters, Pieter De Gauquier, Fardine Ameli, Yvan Vander Heyden, Debby Mangelings, Kenno Vanommeslaeghe   +5 more
doaj   +1 more source

Computing topological descriptors for the molecular structure of anticancer drug [PDF]

, 2019
Iqbal et al.
openalex   +1 more source

A molecular descriptor of intramolecular noncovalent interaction for regulating optoelectronic properties of organic semiconductors [PDF]

, 2023
Meihui Liu, Xiao Han, Hao Chen, Qian Peng, Hui Huang   +4 more
openalex   +1 more source

Signature molecular descriptor : advanced applications. [PDF]

, 2010
In this work we report on the development of the Signature Molecular Descriptor (or Signature) for use in the solution of inverse design problems as well as in highthroughput screening applications. The ultimate goal of using Signature is to identify novel and non-intuitive chemical structures with optimal predicted properties for a given application ...
openaire   +2 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source