Results 121 to 130 of about 3,342,969 (292)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Novel molecular descriptors for prediction of H2S solubility in ionic liquids

, 2018
Molecular descriptors are very important input parameters for establishing properties prediction models of materials, such as ionic liquids (ILs). In this work, as a new class of molecular descriptors, namely, electrostatic potential surface (S-EP) is ...
Qian, JG, Deng, J, Zhao, YS, Zhao, Yongsheng, Kang, Xuejing, Deng, Jing, Qian, Jianguo, Latif, U, Kang, XJ, Latif, Ullah   +9 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Deconstructing adsorption variability: the prediction of spatial uncertainty in pollutant movement [PDF]

, 2008
Land pressures today and government policy-requires previously developed, 'brownfield' land to be brought back into beneficial use. The nature of these sites means that they may have been subject to some form of contamination from previous uses. The risk
Collins, John Philip
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Predictive modeling for physicochemical properties of $$\beta$$ -lactam antibiotics through eigenvalue based topological indices and non linear regression techniques

Scientific Reports
In this work, a quantitative structure property relationship analysis is performed for selected $$\beta$$ -lactam antibiotics using eigenvalue based spectral descriptors derived from molecular graph representations.
A. Yuvaraj, G. Kalaimurugan, R. Thamizhmaran, M. Mubeen Tajudeen, Rodrigo Colnago Contreras   +4 more
doaj   +1 more source

Study on Coupling Relationships Among Target Parameters for Multi-Component Biodiesel Surrogate Fuels

Energies
Real biodiesel contains numerous components with complex molecular structures, and thus a representative surrogate fuel is required to develop tractable chemical kinetic mechanisms for biodiesel combustion.
Bohui Zhao, Yijun Heng, Pan Chen, Junjie Liang, Neng Zhu   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source