Results 151 to 160 of about 3,342,969 (292)

Comparative Study of Molecular Descriptors of Pent-Heptagonal Nanostructures Using Neighborhood M-Polynomial Approach. [PDF]

Molecules, 2023
Xavier DA, Ghani MU, Imran M, Nair A T, Varghese ES, Baby A.   +5 more
europepmc   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Mol2Image: an enhanced DDI prediction framework leveraging drug molecular descriptors. [PDF]

BMC Bioinformatics
Helmy N, Maghawry HA, Badr N.
europepmc   +1 more source

SNARER: new molecular descriptors for SNARE proteins classification. [PDF]

BMC Bioinformatics, 2022
Auriemma Citarella A, Di Biasi L, Risi M, Tortora G.   +3 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Correction to "Sequence-Derived and Molecular Descriptors for Interpretable Modeling of Molecular Systems: Insights from Peptide Hemolysis". [PDF]

J Chem Inf Model
Medvedeva A, Kolomeisky K, Vasnetsov C, Reed A, Bogdanova A, Kolomeisky AB.   +5 more
europepmc   +1 more source

From Molecular Descriptors to Intrinsic Fish Toxicity of Chemicals: An Alternative Approach to Chemical Prioritization. [PDF]

Environ Sci Technol, 2023
Samanipour S, O'Brien JW, Reid MJ, Thomas KV, Praetorius A.   +4 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Machine Learning-Driven Prediction of Dose-Linear Pharmacokinetics: Utilizing Molecular Descriptors to Guide Formulation Strategy. [PDF]

ACS Omega
Levy ES, Samy KE, Anelli A, Leung DH.
europepmc   +1 more source

Fusing 2D and 3D molecular graphs as unambiguous molecular descriptors for conformational and chiral stereoisomers. [PDF]

Brief Bioinform, 2023
Du W, Yang X, Wu D, Ma F, Zhang B, Bao C, Huo Y, Jiang J, Chen X, Wang Y.   +9 more
europepmc   +1 more source