Results 221 to 230 of about 4,091,521 (342)

Prediction of Alternative Drug-Induced Liver Injury Classifications Using Molecular Descriptors, Gene Expression Perturbation, and Toxicology Reports. [PDF]

Front Genet, 2021
Lesiński W, Mnich K, Rudnicki WR.
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Predicting permeation of compounds across the outer membrane of P. aeruginosa using molecular descriptors. [PDF]

Commun Chem
Manrique PD, Leus IV, López CA, Mehla J, Malloci G, Gervasoni S, Vargiu AV, Kinthada RK, Herndon L, Hengartner NW, Walker JK, Rybenkov VV, Ruggerone P, Zgurskaya HI, Gnanakaran S.   +14 more
europepmc   +1 more source

Combined Pharmacophore and Grid-Independent Molecular Descriptors (GRIND) Analysis to Probe 3D Features of Inositol 1,4,5-Trisphosphate Receptor (IP₃R) Inhibitors in Cancer. [PDF]

Int J Mol Sci, 2021
Ismatullah H, Jabeen I.
europepmc   +1 more source

On the Relationship between Molecular Hit Rates in High-Throughput Screening and Molecular Descriptors [PDF]

, 2013
Mari Hansson, John Pemberton, Ola Engkvist, Isabella Feierberg, Lars Brive, Philip Jarvis, Linda Zander Balderud, Hongming Chen   +7 more
openalex   +1 more source

Search for Optimal Molecular Descriptors

Croatica Chemica Acta, 1991
We illustrate, on a set of heptane isomers and van der Waals molecular areas as a property, a search for optimal descriptors to be used in multivariate analyses. We employed molecular connectivities as the basis descriptors and examined their various combinations as alternative descriptors that could lead to a better regression.
openaire   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Prediction of Hydrogen-Bonding Interaction Free Energies with Two New Molecular Descriptors [PDF]

William E. Acree, Costas Panayiotou
openalex   +1 more source

Evaluation of Relevant Molecular Descriptors for the Solvation of Paramagnetic Relaxation Reagents. [PDF]

, 1987
Hans Grahn, Ulf Edlund, Jorma Mattinen, G. BERNÁTH, Lennart Eberson   +4 more
openalex   +1 more source