Results 281 to 290 of about 4,091,521 (342)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

LEL-a Newly Designed Molecular Descriptor

, 2009
Diudea, Mircea V., Ilić, Aleksandar, Onişor, Cristina, Stevanović, Dragan   +3 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

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Impact of Molecular Descriptors on Computational Models

Methods in molecular biology, 2018
Molecular descriptors encode a wide variety of molecular information and have become the support of many contemporary chemoinformatic and bioinformatic applications. They grasp specific molecular features (e.g., geometry, shape, pharmacophores, or atomic properties) and directly affect computational models, in terms of outcome, performance, and ...
Grisoni, F, Consonni, V, Todeschini, R
openaire   +3 more sources

Conserved Sites and Recognition Mechanisms of T1R1 and T2R14 Receptors Revealed by Ensemble Docking and Molecular Descriptors and Fingerprints Combined with Machine Learning.

Journal of Agricultural and Food Chemistry, 2023
Taste peptides, as an important component of protein-rich foodstuffs, potentiate the nutrition and taste of food. Thereinto, umami- and bitter-taste peptides have been ex tensively reported, while their taste mechanisms remain unclear.
Zhiyong Cui, Ninglong Zhang, Tianxing Zhou, Xueke Zhou, Hengli Meng, Yanyang Yu, Zhiwei Zhang, Yin Zhang, Wenli Wang, Yuan Liu   +9 more
semanticscholar   +1 more source

A review on the application of molecular descriptors and machine learning in polymer design

Polymer Chemistry, 2023
Molecular descriptors and machine learning are useful tools for extracting structure–property relationships from large, complex polymer data, and accelerating the design of novel polymers with tailored functionalities.
Yuankai Zhao, R. Mulder, S. Houshyar, T. Le   +3 more
semanticscholar   +1 more source

Topological study on degree based molecular descriptors of fullerene cages

Molecular Physics, 2023
Fullerenes are an allotrope of carbon that create polyhedral cages. Their bond structures match the sole pentagon and hexagonal-faced planar cubic graphs. Several chemical properties of fullerenes can be studied using its graph structure.
Tony Augustine, S. Roy, J. Sahaya Vijay, Jain Maria Thomas, P. Shanmugam   +4 more
semanticscholar   +1 more source

Molecular Descriptors of Porphyrin-based Dendrimer

Polycyclic aromatic compounds (Print), 2022
The molecular descriptors are numerical quantities which provide information and characteristics of chemical structures. The molecular descriptors provides characteristics such as boiling point, solubility, toxicity, melting point, vapor pressure, etc ...
Jia-Bao Liu, D. Xavier, Eddith Sarah Varghese, Annmaria Baby, Deepa Mathew   +4 more
semanticscholar   +1 more source