Results 71 to 80 of about 59,986 (298)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
QSAR study of some chalcones derivatives for prediction of anti-prostate cancer activities [PDF]
شیمی کاربردی روز, 2012 We performed structure-activity studies upon an extended series of 36 compounds of chalcone derivatives with anti cancer biological activities in LNCaP prostate cancer cell line, using QSAR methods that imply analysis of correlations and multiple linear ...
Abbas Amini Manesh +2 more
doaj +1 more source
Molecular descriptors and quasi-distribution functions
Computers & Mathematics with Applications, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
J.M. Sellier, D.Y. Ivanova, I. Dimov
openaire +1 more source
Scalable Similarity Search for Molecular Descriptors [PDF]
, 2017 Similarity search over chemical compound databases is a fundamental task in the discovery and design of novel drug-like molecules. Such databases often encode molecules as non-negative integer vectors, called molecular descriptors, which represent rich information on various molecular properties.
Yasuo Tabei, Simon J. Puglisi
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Genetic divergence of Anthurium affine germplasm using morphoagronomic and molecular descriptors
Revista Ciência Agronômica, 2020 Anthurium affine is an ornamental Brazilian native plant very appreciated due to its long-lasting durability. To explore the genetic diversity available, 21 A.
Clara Yohana Maia +5 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
RED: A Set of Molecular Descriptors Based on Rényi Entropy
, 2016 New molecular descriptors, RED (Rényi entropy descriptors), based on the generalized entropies introduced by Rényi are presented. Topological descriptors based on molecular features have proven to be useful for describing molecular profiles.
Raul Toral (2336545) +3 more
core +3 more sources