Results 1 to 10 of about 1,845,017 (119)

Soy Protein-Based Hydrogels: Recent Advances in Molecular Design and Functional Applications [PDF]

Gels
To address the limitations of conventional polymer hydrogels in terms of sustainability and functionality, green soy protein (SP)-based hydrogels (SPHs) demonstrate significant potential.
Zhongjian Li, Luohui Wang, Liyun Wang, Man Yin, Lin Zhang, Xian Wang, Limin Guo, Xiangmeng Chen, Cheng Li   +8 more
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3D-QSAR-based pharmacophore determination and design of novel DPP-4 inhibitors [PDF]

Scripta Medica, 2022
Background/Aim: Therapy of diabetes mellitus type 2 includes drugs that act as inhibitors of dipeptidyl peptidase 4 (DPP-4) enzyme. Several DPP-4 inhibitors are marketed today and although they have favourable safety profile and tolerability, they show ...
Rogić Sanja, Gagić Žarko
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Cancer immunomodulation using bispecific aptamers

Molecular Therapy: Nucleic Acids, 2022
Evasion of immune destruction is a major hallmark of cancer. Recent US Food and Drug Administration (FDA) approvals of various immunomodulating therapies underline the important role that reprogramming the immune system can play in combating this disease.
Brian J. Thomas, David Porciani, Donald H. Burke   +2 more
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Tailoring the AIE Chromogen 2-(2-Hydroxyphenyl)benzothiazole for Use in Enzyme-Triggered Molecular Brachytherapy

Molecules, 2022
A targeted strategy for treating cancer is antibody-directed enzyme prodrug therapy, where the enzyme attached to the antibody causes conversion of an inactive small-molecule prodrug into an active drug.
Zhiyuan Wu, Jinghuai Dou, Kathy-Uyen Nguyen, Jayden C. Eppley, Kittipan Siwawannapong, Yunlong Zhang, Jonathan S. Lindsey   +6 more
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Molecular Generative Model via Retrosynthetically Prepared Chemical Building Block Assembly

Advanced Science, 2023
Deep generative models are attracting attention as a smart molecular design strategy. However, previous models often render molecules with low synthesizability, hindering their real‐world applications.
Seonghwan Seo, Jaechang Lim, Woo Youn Kim   +2 more
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Nanotechnology for brain tumor imaging and therapy based on π-conjugated materials: state-of-the-art advances and prospects

Frontiers in Chemistry, 2023
In contemporary biomedical research, the development of nanotechnology has brought forth numerous possibilities for brain tumor imaging and therapy.
Wenshe Sun, Wenshe Sun, Congxiao Wang, Chuan Tian, Xueda Li, Xiaokun Hu, Shifeng Liu   +6 more
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Hybrid Quinoline-Thiosemicarbazone Therapeutics as a New Treatment Opportunity for Alzheimer’s Disease‒Synthesis, In Vitro Cholinesterase Inhibitory Potential and Computational Modeling Analysis

Molecules, 2021
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide. The limited pharmacological approaches based on cholinesterase inhibitors only provide symptomatic relief to AD patients.
Sumera Zaib, Rubina Munir, Muhammad Tayyab Younas, Naghmana Kausar, Aliya Ibrar, Sehar Aqsa, Noorma Shahid, Tahira Tasneem Asif, Hashem O. Alsaab, Imtiaz Khan   +9 more
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Paradigm Shift: The Promise of Deep Learning in Molecular Systems Engineering and Design

Frontiers in Chemical Engineering, 2021
The application of deep learning to a diverse array of research problems has accelerated progress across many fields, bringing conventional paradigms to a new intelligent era.
Abdulelah S. Alshehri, Abdulelah S. Alshehri, Fengqi You   +2 more
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Organic Electroactive Molecule-Based Electrolytes for Redox Flow Batteries: Status and Challenges of Molecular Design

Frontiers in Chemistry, 2020
This is a critical review of the advances in the molecular design of organic electroactive molecules, which are the key components for redox flow batteries (RFBs).
Fangfang Zhong, Minghui Yang, Mei Ding, Mei Ding, Chuankun Jia, Chuankun Jia, Chuankun Jia   +6 more
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Spin State Behavior of A Spin-Crossover Iron(II) Complex with N,N′-Disubstituted 2,6-bis(pyrazol-3-yl)pyridine: A Combined Study by X-ray Diffraction and NMR Spectroscopy

Crystals, 2020
A series of three different solvatomorphs of a new iron(II) complex with N,N′-disubstituted 2,6-bis(pyrazol-3-yl)pyridine, including those with the same lattice solvent, has been identified by X-ray diffraction under the same crystallization conditions ...
Elizaveta K. Melnikova, Dmitry Yu. Aleshin, Igor A. Nikovskiy, Gleb L. Denisov, Yulia V. Nelyubina   +4 more
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