Results 161 to 170 of about 8,584,903 (389)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Conformer-specific Infrared spectroscopy of cationic Criegee intermediates syn- and anti-CH3CHOO+

Nature Communications
Criegee intermediates are pivotal in atmospheric chemistry, yet their cationic forms remain poorly understood. This study presents the infrared spectra of cationic Criegee intermediates, specifically syn- and anti-CH3CHOO+, using vacuum ultraviolet ...
Ende Huang, Licheng Zhong, Jingning Xue, Xiaohu Zhou, Siyue Liu, Li Che, Hongwei Li, Hongjun Fan, Wenrui Dong, Xueming Yang   +9 more
doaj   +1 more source

Systematic Examination of Polymorphism in Amyloid Fibrils by Molecular-Dynamics Simulation [PDF]

, 2011
Joshua T. Berryman, Sheena E. Radford, Sarah A. Harris   +2 more
openalex   +1 more source

molecular dynamics

, 2014
Citation: 'molecular dynamics' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.MT06969 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Data-driven construction of a generalized kinetic collision operator from molecular dynamics [PDF]

Yue Zhao, J. W. Burby, Andrew Christlieb, Huan Lei   +3 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

1P375 Single-molecular gating dynamics of KcsA potassium channel measured by diffracted X-ray tracking(14. Ion channels and receptors,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

, 2006
Hirofumi Shimizu, Masayuki Iwamoto, Fumiko Inoue, Takashi Konno, Yuji C. Sasaki, Shigetoshi Oiki   +5 more
openalex   +2 more sources

Benchmarking Quasiclassical Mapping Hamiltonian Methods for Simulating Electronically Nonadiabatic Molecular Dynamics

, 2020
Xing Gao, Maximilian A. C. Saller, Yudan Liu, Aaron Kelly, Jeremy O. Richardson, Eitan Geva   +5 more
openalex   +2 more sources

Accelerating chemical reactions: Exploring reactive free-energy surfaces using accelerated ab initio molecular dynamics [PDF]

, 2011
Levi Pierce, Phineus R. L. Markwick, J. Andrew McCammon, Nikos L. Doltsinis   +3 more
openalex   +1 more source