Results 211 to 220 of about 17,737,336 (290)

Comparative Conformational Sampling of Apo Adenylate Kinase by Enhanced Molecular Dynamics and a Sequence-Based Generative Ensemble Model. [PDF]

Molecules
Zhao Q, Cui T, Li Y.
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Truncating the time-evolving discrete chemical master equation for stochastic biological networks. [PDF]

Biophys J
Farhat AM, Pang Y, Manuchehrfar F, Tang Y, Liang J.   +4 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

MF1, a novel robustic acid derivative, exerts antitumor effects in hepatocellular carcinoma. [PDF]

Transl Oncol
Huang J, Teng L, Meng T, Liang Y, Li Y, Lv J.   +5 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Benchmarking electronic-structure methods for nonadiabatic dynamics in a propeller-shaped molecular rotor: insights into conical intersections.

Faraday Discuss
Brady M, Crespo-Otero R.
europepmc   +1 more source

Identification of potential pathogenic genes for lung adenocarcinoma induced by 6PPD-quinone through network toxicology and SHAP analysis. [PDF]

Front Toxicol
Xiong X, Ding J, Liu W, Li B, Yao C.
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

From Static Structures to Molecular Dynamics: Emerging Directions in X-Ray and Electron Materials Characterization. [PDF]

Materials (Basel)
Sasaki D, Mio K, Sasaki YC.
europepmc   +1 more source