Results 171 to 180 of about 290,643 (260)

Age‐associated immune dysregulation links to disease severity in macrolide‐resistant Mycoplasma pneumoniae pneumonia: Insights from a comparative juvenile–adult mouse model

Animal Models and Experimental Medicine, EarlyView.
Macrolide‐resistant Mycoplasma pneumoniae (MRMP) infected both juvenile and adult mice, with results compared to normal juvenile mice. The findings revealed comparable bacterial loads between juvenile and adult mice, yet juvenile mice exhibited more severe lung damage and elevated levels of inflammatory cytokines.
Xuejun Li, Yudong Wang, Liyong Liu, Mengmeng Gong, Jinlong Wang, Yuqing Cao, Zhixin Sun, Fanliang Meng, Qiuyan Wang, Hongji Wu, Fei Zhao, Yan Ma, Yibai Xiong   +12 more
wiley   +1 more source

Molecular epidemiology of antimicrobial resistance and virulence of carbapenem-resistant <i>Klebsiella pneumoniae</i> in South China. [PDF]

Front Microbiol
He Y, Deng R, Lin W, Yang X, Li Y, Yang Y, Chen C, Huang B.   +7 more
europepmc   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Molecular epidemiology and genetic evolution of PRRSV ORF5 in Sichuan, Southwest China. [PDF]

Front Microbiol
Yu J, Kang R, Qing Y, Xu Q, Xie J, Cao Y, Ye Y, Xiao L, Xie L, Xiang X, Zhou L, Yu C, Huang Y.   +12 more
europepmc   +1 more source

Proinflammatory Epstein–Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens, Paula Terroba‐Navajas, Eline A.J. Willemse, Sabine Schädelin, Manuel Comabella, Christian Münz, Gordan Lauc, Yannic Bartsch, Jens Kuhle, Jan D. Lünemann   +9 more
wiley   +1 more source

A meta-analysis identifies driver genes and characterizes the molecular epidemiology of colorectal cancer. [PDF]

Sci Rep
Olafsson S, Thorarinsson T, Gudjonsson SA, Bustamante M, Gunnarsdottir HS, Knutsdottir H, Jonsson H, Magnusson MI, Soebech E, Runarsdottir H, Magnusdottir DN, le Roux L, Saemundsdottir J, Kristinsdottir BS, Agnarson BA, Jonsdottir EM, Tryggvason T, Ulfarsson MO, Gudbjartsson DF, Jonasson JG, Magnusson O, Stefansson K, Rafnar T.   +22 more
europepmc   +1 more source

Diabetes and the Metabolic Syndrome as Drivers of Neurodegeneration: Convergent Mechanisms Linking Peripheral Neuropathy and Dementia

Annals of Neurology, EarlyView.
The metabolic syndrome, a state of progressive metabolic dysfunction, injures the peripheral and central nervous systems, promoting peripheral neuropathy (PN) and cognitive impairment (CI), respectively. We posit PN and CI are connected in the metabolic syndrome framework, built on the premise that neurons, whether in the peripheral or central nervous ...
Masha G. Savelieff, David L. Bennett, Troels S. Jensen, Eva L. Feldman   +3 more
wiley   +1 more source

Cross-border molecular epidemiology of Plasmodium falciparum drug susceptibility: insights from the Uganda-Democratic Republic of the Congo border. [PDF]

Malar J
Dilufwasayo PM, Balikagala B, Uchopa MA, Amaa JA, Ngoyi DM, Mita T.   +5 more
europepmc   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

Molecular epidemiology and genetic characteristics of influenza viruses in a local pediatric population of eastern China, 2024. [PDF]

Front Microbiol
Sun X, Li X, Chen H, Lu T, Fang Z, Chen D, Cai Q, Shen J, Xie Y.   +8 more
europepmc   +1 more source