Results 91 to 100 of about 631,800 (281)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Multiplicative Zagreb Indices of Molecular Graphs
Journal of Chemistry, 2019 Mathematical modeling with the help of numerical coding of graphs has been used in the different fields of science, especially in chemistry for the studies of the molecular structures. It also plays a vital role in the study of the quantitative structure
Xiujun Zhang +3 more
doaj +1 more source
Deterministic atom-light quantum interface
, 2006 The notion of an atom-light quantum interface has been developed in the past decade, to a large extent due to demands within the new field of quantum information processing and communication.
Julsgaard, Brian +2 more
core +1 more source
, 2014 Citation: 'molecular graph theory' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.MT07070 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular graphs, point groups, and fullerenes
The Journal of Chemical Physics, 1992 A general and convenient method is described by which one can obtain the point group, the 13C NMR pattern, and the number of IR- and Raman-active vibrations of any given fullerene structure directly from its molecular graph. The method is based on certain ‘‘topological’’ atomic coordinates, the Cartesian components of which in a topological principal ...
Manolopoulos, D, Fowler, P
openaire +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
On the multiplicative sum Zagreb index of molecular graphs
Open MathematicsMultiplicative sum Zagreb index is a modified version of the famous Zagreb indices. For a graph GG, the multiplicative sum Zagreb index is defined as Π1*(G)=∏uv∈E(G)(dG(u)+dG(v)){\Pi }_{1}^{* }\left(G)={\prod }_{uv\in E\left(G)}\left({d}_{G}\left(u)+{d}_{
Sun Xiaoling, Du Jianwei, Mei Yinzhen
doaj +1 more source
Hierarchical graphs for rule-based modeling of biochemical systems
BMC Bioinformatics, 2011 Background In rule-based modeling, graphs are used to represent molecules: a colored vertex represents a component of a molecule, a vertex attribute represents the internal state of a component, and an edge represents a bond between components ...
Hu Bin +2 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source