Results 61 to 70 of about 631,800 (281)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Efficient learning of non-autoregressive graph variational autoencoders for molecular graph generation

Journal of Cheminformatics, 2019
With the advancements in deep learning, deep generative models combined with graph neural networks have been successfully employed for data-driven molecular graph generation.
Youngchun Kwon, Jiho Yoo, Youn-Suk Choi, Won-Joon Son, Dongseon Lee, Seokho Kang   +5 more
doaj   +1 more source

Frequent Subgraph Mining in Outerplanar Graphs [PDF]

, 2010
In recent years there has been an increased interest in frequent pattern discovery in large databases of graph structured objects. While the frequent connected subgraph mining problem for tree datasets can be solved in incremental polynomial time, it ...
Horvath, Tamas, Ramon, Jan, Wrobel, Stefan   +2 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Enhancing property and activity prediction and interpretation using multiple molecular graph representations with MMGX

Communications Chemistry
Graph Neural Networks (GNNs) excel in compound property and activity prediction, but the choice of molecular graph representations significantly influences model learning and interpretation.
Apakorn Kengkanna, Masahito Ohue
doaj   +1 more source

VERTEX-ECCENTRICITY DESCRIPTORS IN DENDRIMERS

Studia Universitatis Babes-Bolyai Chemia, 2017
In this paper, we present graph theoretical methods to compute several vertex-eccentricity-based molecular descriptors such as the eccentric connectivity index, total eccentricity, average eccentricity and first and second Zagreb eccentricity indices ...
Mahdieh AZARI, Ali IRANMANESH, Mircea V. DIUDEA   +2 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Computing Bounds for General Randic Coindex of Sum Graphs

Journal of Mathematics, 2021
The physical and structural properties of molecular structure or graph such as boiling point, melting point, surface tension, or solubility are studied using topological index (TI).
Muhammad Javaid, Muhammad Ibraheem, Ebenezer Bonyah   +2 more
doaj   +1 more source

Topological Symmetry Groups of Complete Bipartite Graphs [PDF]

, 2015
The symmetries of complex molecular structures can be modeled by the {\em topological symmetry group} of the underlying embedded graph. It is therefore important to understand which topological symmetry groups can be realized by particular abstract ...
Hake, Kathleen, Mellor, Blake, Pittluck, Matthew   +2 more
core   +2 more sources