Results 111 to 120 of about 3,984,960 (324)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Controlled Zn(II) to Co(II) Transmetalation in a Metal–Organic Framework Inducing Single-Ion Magnet Behavior

Magnetochemistry
The intrinsic characteristic features of metal–organic frameworks offer unique, great opportunities to develop novel materials with applications in very diverse fields.
Paula Escamilla, Nicolás Moliner, Donatella Armentano, Emilio Pardo, Jesús Ferrando-Soria, Thais Grancha   +5 more
doaj   +1 more source

Spectropolarimetric observations of cool DQ white dwarfs

, 2013
Following our recent discovery of a new magnetic DQ white dwarf (WD) with CH molecular features, we report the results for the rest of the DQ WDs from our survey.
Berdyugin, Andrei, Berdyugina, Svetlana, Vornanen, Tommi   +2 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Dipolar atomic spin ensembles in a double-well potential

, 2014
We experimentally study the spin dynamics of mesoscopic ensembles of ultracold magnetic spin-3 atoms located in two separated wells of an optical dipole trap.
A. Carrance, A. de Paz, B. Laburthe-Tolra, B. Naylor, E. Maréchal, J. Huckans, L. Vernac, O. Gorceix, P. Pedri   +8 more
core   +3 more sources

Molecular magnets

, 2020
Among all C-, N-, and O-centered polyradicals, high-spin nitrenes possess the largest magnetic anisotropy and are of considerable interest as multi-level molecular spin systems for exploration of organic molecular magnetism and quantum information processing.
Chapyshev, Sergei V. (Dr. rer. nat.), Méndez-Vega, Enrique (Dr. rer. nat.), Sander, Wolfram (Prof. Dr. rer. nat.)   +2 more
openaire   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Magnetic ordering in some organic molecular magnets

Synthetic Metals, 1995
Summary form only given. In order to elucidate correlation between magnetic ordering and a crystal structure of organic molecular magnets, we have investigated muon spin rotation (vSR), electron spin resonance (ESR) and a.c. susceptibility of the organic neutral radicals, 3-quinolyl nitronyl nitroxide (3-QNNN) andp-pyridyl nitron'l nitroxide (p-PYNN).
Sugano, T, Pratt, F, Kurmoo, M, Takeda, N, Ishikawa, M, Blundell, S, Pattenden, P, Valladares, R, Hayes, W, Day, P   +9 more
openaire   +1 more source