Results 111 to 120 of about 1,120,591 (303)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Molecular maps of myosin.

Seibutsu Butsuri, 1988
Three functionally important sites of myosin head, i.e. ATPase site, actin-binding site and SH1 thiol, were identified in its three-dimensional structure by electron microscopy. These sites were also mapped along primary structures of myosin heavy and light chains by chemical methods such as affinity labeling, chemical crosslinking and "end-label ...
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

DNA analyses and their applications in plant breeding

Czech Journal of Genetics and Plant Breeding, 2002
In recent years, molecular markers have been developed based on the more detailed knowledge of genome structure. Considerable emphasis has been laid on the use of molecular markers in practical breeding and genotype identification.
J. Ovesná, K. Poláková, L. Leišová
doaj   +1 more source

Exactly solvable effective mass D-dimensional Schrodinger equation for pseudoharmonic and modified Kratzer problems

, 2008
We employ the point canonical transformation (PCT) to solve the D-dimensional Schr\"{o}dinger equation with position-dependent effective mass (PDEM) function for two molecular pseudoharmonic and modified Kratzer (Mie-type) potentials.
Bastard G., Ikhdair S. M., Ikhdair S. M., Ikhdair S. M., Ikhdair S. M., Ikhdair S. M., Ikhdair S. M., Koç R., Koç R., Li Y. M., Plastino A. R., RAMAZAN SEVER, SAMEER M. IKHDAIR, Weisbuch C.   +13 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Investigating the Potential of Using the Spatial and Spectral Information of Multispectral LiDAR for Object Classification

Sensors, 2015
The abilities of multispectral LiDAR (MSL) as a new high-potential active instrument for remote sensing have not been fully revealed. This study demonstrates the potential of using the spectral and spatial features derived from a novel MSL to ...
Wei Gong, Jia Sun, Shuo Shi, Jian Yang, Lin Du, Bo Zhu, Shalei Song   +6 more
doaj   +1 more source

The Kennicutt-Schmidt Star Formation Relation at z~2

, 2011
Recent observations of excited CO emission lines from z~2 disc galaxies have shed light on the Kennicutt-Schmidt relation at high-z via observed SFR-CO (J=2-1) and (J=3-2) relations.
Andre, Andreani, Bayet, Bernes, Bigiel, Blitz, Blitz, Bothwell, Bouché, Bussmann, Carilli, Christopher C. Hayward, Cox, Daddi, Daddi, Dannerbauer, Davé, Desika Narayanan, Downes, Elmegreen, Elmegreen, Erb, Evans, Fuller, Förster Schreiber, Gao, Gao, Genzel, Graciá-Carpio, Greve, Hainline, Harris, Hernquist, Iono, Jonsson, Jonsson, Juneau, Kennicutt, Kennicutt, Keres, Krumholz, Krumholz, Krumholz, Lars Hernquist, Lee, Leroy, McKee, Mo, Narayanan, Narayanan, Narayanan, Narayanan, Narayanan, Narayanan, Narayanan, Narayanan, Narayanan, Noeske, Noeske, Papadopoulos, Rosolowsky, Rosolowsky, Sanders, Schaye, Schmidt, Schöier, Silk, Solomon, Springel, Springel, Springel, Springel, Tacconi, Tan, Thomas J. Cox, van Zadelhoff, Walker, Weiß, Wu, Wu, Yao   +80 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source