Results 181 to 190 of about 1,120,591 (303)

Genetic analysis and molecular mapping of the purple leaf sheath in barley (Hordeum vulgare). [PDF]

Plant Genome
Mewa DB, Caspersen A, Fiedler JD, Hu G, Gao D.   +4 more
europepmc   +1 more source

HPV Genotyping by Molecular Mapping of Tissue Samples in Vaginal Squamous Intraepithelial Neoplasia (VaIN) and Vaginal Squamous Cell Carcinoma (VaSCC). [PDF]

Cancers (Basel), 2021
Zhang S, Saito M, Okayama K, Okodo M, Kurose N, Sakamoto J, Sasagawa T.   +6 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Molecular mapping of a novel locus S68 for intrasubspecific hybrid sterility in indica-indica hybrid. [PDF]

Sci Rep
Song X, Yang Y, Pu Q, Zhou J, Lv Y, Jiang X, Li J, Deng X, Tao D, Zhang Y.   +9 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Molecular mapping of candidate genes in determining red color of perilla leaf. [PDF]

Adv Biotechnol (Singap)
Xie G, Zhang Y, Xiao S, Wu D, Wang H, Shen Q.   +5 more
europepmc   +1 more source

Molecular Mapping and Analysis of an Excellent Quantitative Trait Loci Conferring Adult-Plant Resistance to Stripe Rust in Chinese Wheat Landrace Gaoxianguangtoumai. [PDF]

Front Plant Sci, 2021
Wang Y, Liang F, Guan F, Yao F, Long L, Zhao X, Duan L, Wu Y, Li H, Li W, Jiang Q, Wei Y, Ma J, Qi P, Deng M, Zheng Y, Kang H, Jiang Y, Chen G.   +18 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Molecular mapping and validation of quantitative trait loci for content of micronutrients in wheat grain. [PDF]

Front Plant Sci
Chen X, You J, Dong N, Wu D, Zhao D, Yong R, Hu W.   +6 more
europepmc   +1 more source

Molecular Mapping and Genomics of Grain Yield in Durum Wheat: A Review. [PDF]

Int J Mol Sci, 2020
Arriagada O, Marcotuli I, Gadaleta A, Schwember AR.   +3 more
europepmc   +1 more source