Results 161 to 170 of about 1,325,148 (262)

Joint prediction of glioma molecular marker status based on GDI-PMNet. [PDF]

J Transl Med
Zhu H, Liang F, Zhao T, Cao Y, Chen Y, Yan H, Xiao X.   +6 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A Clinicopathology and Simplified Molecular Marker-Based Risk Stratification Model for Predicting 3-Year Recurrence in Endometrial Cancer. [PDF]

Clin Med Insights Oncol
Zhang J, Zhou Y, Huang Y, Qin X, Yang H, Yang C, Guo J.   +6 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Enhancing hybridization potential through standardizing emasculation techniques and molecular marker integration in finger millet (Eleusine coracana L.). [PDF]

Plant Methods
Pranati J, Joshi P, Kudapa H, Ingole HP, Panthulugiri S, Vetriventhan M, Ramya K, Muqsith SA, Pannem S, Vemula A, Jadhav Y, Sriswathi M, Gupta SK, Mayes S, Singh K, Sajja S.   +15 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Deep-Learning Solution Providing Molecular Marker Subtyping of Breast Cancer Whole Slide Images: Protocol for a UK Clinical Service Evaluation Study. [PDF]

JMIR Res Protoc
Walsh E, Rathore D, Geraldes A, Arslan S, Hanby AM, Millican-Slater R, Drummond M, Rotimi O, Kumar N, Pandya P, Orsi NM.   +10 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

MYB polymorphism molecular marker: A novel molecular marker for authenticity and geographical origin identification of <i>Citri Reticulatae Pericarpium</i>. [PDF]

Chin Herb Med
Cheng Q, Tang Z, Ouyang Y, Cheng C, Lao C, Cui H, Zhou H, Liang Y.   +7 more
europepmc   +1 more source