Results 261 to 270 of about 1,994,871 (347)

A powerful molecular marker to detect mutations at sorghum LOW GERMINATION STIMULANT 1. [PDF]

Plant Genome
Adeyanju AO, Rich PJ, Ejeta G.
europepmc   +1 more source

Molecular Profiling of Cotton Genotypes for Fibre Properties Using Diagnostic Set of Microsatellite (SSR) Markers

, 2018
H. B. Kumbhalkar, V. L. Gawande, S. J. Gahukar, V. N. Waghmare, S. R. Mawle, Krishnananda Pralhad Ingle   +5 more
openalex   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Genetic mapping and molecular marker development for white flesh color in tomato. [PDF]

Front Plant Sci
Liu J, Fang X, Yu F, Zhang C, Fan P, Wang N, Shao Q, Gan N, Lv X, Ouyang B, Zhang M, Wu X, Liao N.   +12 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH): A Promising Molecular Marker and Therapeutic Target for Hepatocellular Carcinoma. [PDF]

Cancers (Basel)
Davis E, Ermi AG, Sarkar D.
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Potential and application of abortive transcripts as a novel molecular marker of cancers. [PDF]

World J Exp Med
Zhang TM, Zhu XN, Qin SW, Guo XF, Xing XK, Zhao LF, Tan SK.   +6 more
europepmc   +1 more source

Genome Mapping and Molecular Markers for Ascochyta Blight Resistance in Pea (Pisum Sativum L.)

, 2012
Andre Luis Rodrigues Miranda
openalex   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source