Results 41 to 50 of about 1,325,148 (262)

Molecular markers for prostate cancer [PDF]

Cancer Letters, 2007
Serum PSA testing has been used for over 20 years as an aid in the diagnosis and management of prostate cancer. Although highly sensitive, it suffers from a lack of specificity, showing elevated serum levels in a variety of other conditions including prostatitis, benign prostate hyperplasia, and non-cancerous neoplasia.
Reynolds, M.A., Kastury, K., Groskopf, J., Schalken, J.A., Rittenhouse, H.G.   +4 more
openaire   +3 more sources

Research progress on heterogeneity of aging

Neike lilun yu shijian
With the development of Chinese society, the proportion of the population aged 65 and above is increasing, and China is gradually entering an aging society. How to achieve healthy aging and how to delay aging have become important social issues.
Tingxu WANG, Xu WANG, Lianyao ZHOU, Shuo YIN, Jingyu DAI, Jing YE   +5 more
doaj   +1 more source

Identification of a new allele of the Dw gene causing brachytic dwarfing in peach

BMC Research Notes, 2018
Objective Peach brachytic dwarfism determined by Dwarf gene (Dw) is an undesired trait segregating in some peach breeding programs. Recently, a single nucleotide polymorphism (SNP) mutation in the gibberellin insensitive dwarf 1 (GID1) peach gene causing
Celia M. Cantín, Pere Arús, Iban Eduardo   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Molecular markers of sperm quality [PDF]

Reproduction in Domestic Ruminants, 2010
Light microscopic semen evaluation provides useful information about a given sperm sample, but due to its subjective nature has limited prognostic value for the reproductive performance of males or the outcome of assisted fertilization. Cryptic sperm abnormalities (occurring at the molecular level) are not easily detectable by light microscopy, but can
P, Sutovsky, K, Lovercamp
openaire   +2 more sources

Development of two sequence-specific PCR markers linked to the le gene that reduces pod shattering in narrow-leafed Lupin (Lupinus angustifolius L.)

Genetics and Molecular Biology, 2007
Wild types of narrow-leaf lupin (Lupinus angustifolius L.) have seed pods that shatter upon maturity, leading to the loss of their seeds before or during the harvest process.
Jeffrey G. Boersma, Bevan J. Buirchell, Krishnapillai Sivasithamparam, Huaan Yang   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Relevant molecular markers and targets [PDF]

Gynecologic Oncology, 2006
Ovarian cancer is a heterogeneous disease with extensive cytogenetic and molecular heterogeneity including aneuploidy, chromosomal alterations, mutations and overexpression as well as a natural propensity to disseminate and spread, making it difficult to diagnose at an early stage. Insights into the molecular mechanisms operative in cancer development,
Kathleen M, Darcy, Russel J, Schilder
openaire   +2 more sources

Varietal identification of coffee seeds by RAPD technique

Brazilian Archives of Biology and Technology, 2004
This study aimed the identification of cultivars and/or lines of Coffea arabica of commercial interest, using PCR-RAPD markers. The DNA of ground seeds lots of 12 cultivars and/or lines were evaluated with five primers (Operon OPA 01, OPA 04, OPG 11, OPY
Maria Lúcia Crochemore, Liliane Moreira Nunes, Giselly Aparecida Andrade, Hugo Bruno Correa Molinari, Maria Elizabeth Vasconcellos   +4 more
doaj   +1 more source