Results 81 to 90 of about 1,749,054 (354)

The glucocorticoid receptor in inflammatory processes : transrepression is not enough [PDF]

, 2015
Glucocorticoids (GCs) are the most commonly used anti-inflammatory agents to treat inflammatory and immune diseases. However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes, by
Dejager, Lien, Hübner, Sabine, Libert, Claude, Tuckermann, Jan P   +3 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

iScience
Summary: Emerging data suggest a significant cross-talk between metabolic and epigenetic programs. However, the relationship between the mechanistic target of rapamycin (mTOR), which is a pivotal metabolic regulator, and epigenetic modifications remains ...
HaEun Kim, Benjamin Lebeau, David Papadopoli, Predrag Jovanovic, Mariana Russo, Daina Avizonis, Masahiro Morita, Farzaneh Afzali, Josie Ursini-Siegel, Lynne-Marie Postovit, Michael Witcher, Ivan Topisirovic   +11 more
doaj   +1 more source

Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis

iScience, 2021
Summary: Distinct sub-assemblies (modules) of mitochondrial complex I (CI) are assembled with the assistance of CI Assembly Factors (CIAFs) through mechanisms that are incompletely defined.
Anjaneyulu Murari, Shauna-Kay Rhooms, Christian Garcia, Tong Liu, Hong Li, Bibhuti Mishra, Cassie Deshong, Edward Owusu-Ansah   +7 more
doaj   +1 more source

Epigenetic reprogramming of muscle progenitors: inspiration for clinical therapies [PDF]

, 2015
In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest.
Consalvi, Silvia, Saccone, Valentina, Sandona', Martina   +2 more
core   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

NF-κB-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repression

iScience
Summary: While ligand-activated glucocorticoid receptor (GR) binds DNA to activate transcription, glucocorticoids, including budesonide, reduce inflammatory gene expression, yet recruit GR to many such gene loci.
Mahmoud M. Mostafa, Amandah Necker-Brown, Alex Gao, Andrew J. Thorne, Akanksha Bansal, Lucy Swift, Annika M. Maj, Sarah K. Sasse, Pina Colarusso, Anthony N. Gerber, Robert Newton   +10 more
doaj   +1 more source

PRMT1 Is Critical for the Transcriptional Activity and the Stability of the Progesterone Receptor

iScience, 2020
Summary: The progesterone receptor (PR) is an inducible transcription factor that plays critical roles in female reproductive processes and in several aspects of breast cancer tumorigenesis.
Lucie Malbeteau, Coralie Poulard, Cécile Languilaire, Ivan Mikaelian, Frédéric Flamant, Muriel Le Romancer, Laura Corbo   +6 more
doaj   +1 more source

Chromatin remodeling is restricted by transient GATA6 binding during iPSC differentiation to definitive endoderm

iScience, 2022
Summary: In addition to cooperatively driving transcriptional programs, emerging evidence supports transcription factors interacting with one another to modulate the outcome of binding events.
James A. Heslop, Behshad Pournasr, Stephen A. Duncan   +2 more
doaj   +1 more source

Epigenetics: What it is about? [PDF]

, 2014
Epigenetics has captured the attention of scientists in the past decades, yet its scope has been continuously changing. In this paper, we give an overview on how and why its definition has evolved and suggest several clarification on the concepts used in
Ogryzko, Vasily, Saade, Evelyne
core   +3 more sources