Results 241 to 250 of about 33,280,657 (326)

Binding of Selected Ligands to Human Protein Disulfide Isomerase and Microsomal Triglyceride Transfer Protein Complex and the Associated Conformational Changes: A Computational Molecular Modelling Study. [PDF]

ChemistryOpen
Yang YX, Li P, Zhu BT.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Exploring Novel Coumarin-Tethered Bis-Triazoles: Apoptosis Induction in Human Pancreatic Cancer Cells, Antimicrobial Effects, and Molecular Modelling Investigations. [PDF]

ChemMedChem
Dhawan S, Singh A, Manhas N, Seboletswe P, Khubone L, Kumar G, Jonnalagadda SB, Raza A, Sharma AK, Singh P.   +9 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Molecular cloning, characterisation and molecular modelling of two novel T-synthases from mollusc origin. [PDF]

Glycobiology
Zemkollari M, Oostenbrink C, Grabherr R, Staudacher E.   +3 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Exploring the mechanism of action of <i>Vanda tessellata</i> extract for the treatment of osteoarthritis through network pharmacology, molecular modelling and experimental assays. [PDF]

Heliyon
Padhee S, Mohanty D, Sahoo A, Jena S, Chandra Panda P, Ray A, Nayak S.   +6 more
europepmc   +1 more source

Modelling the Molecular Transportation of Subcutaneously Injected Salubrinal

Biomedical Engineering and Computational Biology, 2011
Andy Chen, Ping Zhang, Zhiyao Duan, Guofeng Wang, Hiroki Yokota   +4 more
doaj  

Synthesis of tetrazole hybridized with thiazole, thiophene or thiadiazole derivatives, molecular modelling and antimicrobial activity. [PDF]

Saudi Pharm J
Abualnaja MM, Alalawy AI, Alatawi OM, Alessa AH, Fawzi Qarah A, Alqahtani AM, Bamaga MA, El-Metwaly NM.   +7 more
europepmc   +1 more source

The Comparison of Catalytic Activity of Carbimazole and Methimazole on Electroreduction of Zinc (II) in Chlorates (VII): Experimental and Molecular Modelling Study. [PDF]

Molecules
Nieszporek J, Pańczyk T, Nieszporek K.
europepmc   +1 more source