Metric clusters in evolutionary games on scale-free networks. [PDF]
Nat Commun, 2017 The evolution of cooperation in social dilemmas in structured populations has been studied extensively in recent years. Whereas many theoretical studies have found that a heterogeneous network of contacts favors cooperation, the impact of spatial effects
Kleineberg KK.
europepmc +3 more sources
Cancer Clinical Trials Optimization and Pharmacogenomics [PDF]
, 2012 A critical overview of recent clinical trials in cancer is presented focused on signaling pathways blockers or inhibitors with a view to developing successful clinical trials employing personalized cancer therapies.
I. C. Baianu
core +4 more sources
Optimizing information flow in small genetic networks. II: Feed forward interactions [PDF]
, 2009 Central to the functioning of a living cell is its ability to control the readout or expression of information encoded in the genome. In many cases, a single transcription factor protein activates or represses the expression of many genes.
A. V. Hill +14 more
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Accelerating, hyperaccelerating, and decelerating networks [PDF]
, 2005 Many growing networks possess accelerating statistics where the number of links added with each new node is an increasing function of network size so the total number of links increases faster than linearly with network size.
A. Wagner +6 more
core +1 more source
Stress-induced rearrangements of cellular networks: consequences for protection and drug design [PDF]
, 2007 The complexity of the cells can be described and understood by a number of networks such as protein-protein interaction, cytoskeletal, organelle, signalling, gene transcription and metabolic networks.
Albanese +51 more
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New approach for phylogenetic tree recovery based on genome-scale metabolic networks [PDF]
, 2014 [EN] A wide range of applications and research has been done with genome-scale metabolic models. In this work, we describe an innovative methodology for comparing metabolic networks constructed from genome-scale metabolic models and how to apply this ...
Arnaud Montagud +7 more
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Inherent size constraints on prokaryote gene networks due to "accelerating" growth
, 2004 Networks exhibiting "accelerating" growth have total link numbers growing faster than linearly with network size and can exhibit transitions from stationary to nonstationary statistics and from random to scale-free to regular statistics at particular ...
Gagen, M. J., Mattick, J. S.
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The efficiency of multi-target drugs: the network approach might help drug design
, 2005 Despite considerable progress in genome- and proteome-based high-throughput screening methods and rational drug design, the number of successful single target drugs did not increase appreciably during the past decade.
Agoston, Vilmos +2 more
core +1 more source
Oscillations in I/O monotone systems under negative feedback [PDF]
, 2007 Oscillatory behavior is a key property of many biological systems. The Small-Gain Theorem (SGT) for input/output monotone systems provides a sufficient condition for global asymptotic stability of an equilibrium and hence its violation is a necessary ...
Angeli, David, Sontag, Eduardo D.
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Multiple, weak hits confuse complex systems: A transcriptional regulatory network as an example
, 2005 Robust systems, like the molecular networks of living cells are often resistant to single hits such as those caused by high-specificity drugs. Here we show that partial weakening of the Escherichia coli and Saccharomyces cerevisiae transcriptional ...
P. Erdős +5 more
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