Results 61 to 70 of about 380,132 (123)

A multidimensional strategy for uncovering comprehensive quality markers of Scutellariae Radix based on UPLC-Q-TOF-MS analysis, artificial neural network, network pharmacology analysis, and molecular simulation

Frontiers in Plant Science
Introduction Scutellariae Radix (SR), derived from the root of Scutellaria baicalensis Georgi, is a traditional Chinese medicine (TCM) for clearing heat and cooling blood.
Meiqi Liu, Xiaoran Zhao, J. Wen, Lili Sun, Rui Huang, Huijie Zhang, Yi Liu, Xiao-liang Ren   +7 more
semanticscholar   +1 more source

Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-α

BMC Immunology, 2008
BackgroundDespite being a mainstay for treating superficial bladder carcinoma and a promising agent for interstitial cystitis, the precise mechanism of Bacillus Calmette-Guerin (BCG) remains poorly understood.
M. Saban, M. O'Donnell, R. Hurst, Xue-Ru Wu, Cindy Simpson, I. Dozmorov, C. Davis, Ricardo Saban   +7 more
semanticscholar   +1 more source

Failed "nonaccelerating" models of prokaryote gene regulatory networks

, 2004
Much current network analysis is predicated on the assumption that important biological networks will either possess scale free or exponential statistics which are independent of network size allowing unconstrained network growth over time. In this paper,
Gagen, M. J., Mattick, J. S.
core  

A Nernst heat theorem for nonequilibrium jump processes

, 2023
We discuss via general arguments and examples when and why the steady nonequilibrium heat capacity vanishes with temperature. The framework is the one of Markov jump processes on finite connected graphs where the condition of local detailed balance ...
Khodabandehlou, Faezeh, Maes, Christian, Netočný, Karel   +2 more
core  

Considerate Approaches to Achieving Sufficiency for ABC model selection

, 2011
For nearly any challenging scientific problem evaluation of the likelihood is problematic if not impossible. Approximate Bayesian computation (ABC) allows us to employ the whole Bayesian formalism to problems where we can use simulations from a model ...
Chris Barnes, Michael Stumpf, Michael Stumpf, Sarah Filippi, Tom Thorne   +4 more
core   +1 more source

The Discovery of Acremochlorins O-R from an Acremonium sp. through Integrated Genomic and Molecular Networking

Journal of Fungi
The fermentation of a soil-derived fungus Acremonium sp. led to the isolation of thirteen ascochlorin congeners through integrated genomic and Global Natural Product Social (GNPS) molecular networking.
Ge Cui, Luning Zhou, Hanwei Liu, Xuan Qian, Pengfei Yang, Leisha Cui, Pianpian Wang, Dehai Li, Jaclyn M. Winter, Guangwei Wu   +9 more
semanticscholar   +1 more source

Complexity in genetic networks: topology vs. strength of interactions [PDF]

arXiv, 2013
Genetic regulatory networks are defined by their topology and by a multitude of continuously adjustable parameters. Here we present a class of simple models within which the relative importance of topology vs. interaction strengths becomes a well-posed problem.
arxiv  

On the Realisability of Chemical Pathways

, 2023
The exploration of pathways and alternative pathways that have a specific function is of interest in numerous chemical contexts. A framework for specifying and searching for pathways has previously been developed, but a focus on which of the many pathway
Andersen, Jakob L., Banke, Sissel, Fagerberg, Rolf, Flamm, Christoph, Merkle, Daniel, Stadler, Peter F.   +5 more
core  

Extremal Properties of Complex Networks [PDF]

arXiv, 2011
We describe the structure of connected graphs with the minimum and maximum average distance, radius, diameter, betweenness centrality, efficiency and resistance distance, given their order and size. We find tight bounds on these graph qualities for any arbitrary number of nodes and edges and analytically derive the form and properties of such networks.
arxiv  

The Comprehensive Profiling of the Chemical Components in the Raw and Processed Roots of Scrophularia ningpoensis by Combining UPLC-Q-TOF-MS Coupled with MS/MS-Based Molecular Networking

Molecules
Scrophulariae Radix (SR), the dried root of Scrophularia ningpoensis Hemsl (S. ningpoensis), has been extensively used as traditional Chinese medicine for thousands of years. However, since the mid-20th century, the traditional processing technology of S.
Mina Zhang, Kaixian Chen, Chenguo Feng, Fang Zhang, Liuqiang Zhang, Yiming Li   +5 more
semanticscholar   +1 more source