Results 151 to 160 of about 1,740,047 (309)

Molecular polymorphisms and phenotypes

, 2000
Les relations entre génotype et phénotype, initialement formalisées par la génétique mendélienne, peuvent être décrites plus précisément grâce à l’identification de la nature moléculaire d’une mutation et à l’étude des conséquences fonctionnelles de cette mutation. Sur un plan fonctionnel, les mutations peuvent être classées en trois catégories : perte
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The molecular phenotype of kisspeptin neurons in the medial amygdala of female mice. [PDF]

Front Endocrinol (Lausanne), 2023
Hatcher KM, Costanza L, Kauffman AS, Stephens SBZ.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Molecular genetics and clinical spectrum of neurofibromatosis type 1 in patients: a case-based review

Zdorovʹe Rebenka
Background. Neurofibromatosis type 1 is a common autosomal-dominant neurocutaneous disorder with broad molecular and clinical heterogeneity. Pediatric patients frequently present early with pigmentary findings, neurodevelopmental issues, and risk of ...
N.I. Kitsera, M.I. Drobchak, M.V. Bondarenko, R.V. Kozovyi, L.Ye. Kovalchuk, O.I. Dorosh, I.L. Kozova   +6 more
doaj   +1 more source

Macrophage-derived TNF-enriched tumour microenvironment shapes pancreatic ductal adenocarcinoma into the basal-like molecular phenotype through upregulating TAp63. [PDF]

Clin Transl Med, 2023
Lim SB, Choi JI, Go Y, Ha YJ, Yang MJ, Park SH, Kim S, Kim YS, Lee D.   +8 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Identification and molecular marker analysis of PHS resistance of high generation wheat materials

Scientific Reports
Pre-harvest sprouting (PHS) of wheat will significantly reduce the yield and quality of wheat and threaten the safety of wheat production in China. Screening and utilization of resistant germplasm and functional molecular markers is the fundamental way ...
Heng Zhou, Qiqi Zhang, Fangfang Liu, Wenxin Cao, Yao Li, Yingxiu Wan   +5 more
doaj   +1 more source

Aggregated Molecular Phenotype Scores: Enhancing Assessment and Visualization of Mass Spectrometry Imaging Data for Tissue-Based Diagnostics. [PDF]

Anal Chem, 2023
Chappel JR, King ME, Fleming J, Eberlin LS, Reif DM, Baker ES.   +5 more
europepmc   +1 more source