Results 181 to 190 of about 1,740,047 (309)

Molecular Pharmacological Phenotyping of EBI2 [PDF]

Journal of Biological Chemistry, 2006
Mette M. Rosenkilde, Tau Benned-Jensen, Helene Andersen, Peter J. Holst, Thomas N. Kledal, Hans R. Lüttichau, Jørgen K. Larsen, Jan P. Christensen, Thue W. Schwartz   +8 more
openaire   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Variation in the Molecular Phenotype of βglu-1, an Insect Defence-Related Beta-Glucosidase Gene, in Two Transcontinental Picea Species. [PDF]

Mol Ecol
Wu ETY, Hung TH, Erbilgin N, Ullah A, Jansons Ā, Ali HAA, Clegg SM, MacKay JJ.   +7 more
europepmc   +1 more source

Distinct molecular phenotype and the potential prognostic value of immune prognostic index and tumor infiltrating lymphocytes in hepatoid adenocarcinoma of stomach. [PDF]

Transl Oncol, 2022
Kang M, Ma X, Shi J, Chen G, Jin X, Wang J, Lin L, Wu Z, Chen K, Xu J, Huang P, Chen J.   +11 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Relating the molecular phenotype of ulcerative colitis to the clinical course. [PDF]

Sci Rep
Madill-Thomsen KS, Venner JM, Parsons DE, Famulski KS, Thiesen AL, Hoque S, Kroeker KI, Wong K, Peerani F, Dieleman LA, Hoentjen F, Baumgart DC, Halloran PF, Halloran BP.   +13 more
europepmc   +1 more source

The Trifecta Study: Comparing Plasma Levels of Donor-derived Cell-Free DNA with the Molecular Phenotype of Kidney Transplant Biopsies. [PDF]

J Am Soc Nephrol, 2022
Halloran PF, Reeve J, Madill-Thomsen KS, Demko Z, Prewett A, Billings P, Trifecta Investigators.   +6 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Effect of felzartamab on the molecular phenotype of antibody-mediated rejection in kidney transplant biopsies. [PDF]

Nat Med
Diebold M, Gauthier PT, Mayer KA, Mackova M, Hinze C, Chang J, Patel UD, Schütz E, Jilma B, Schrezenmeier E, Budde K, Böhmig GA, Halloran PF.   +12 more
europepmc   +1 more source

Integration of p16/HPV DNA Status with a 24-miRNA-Defined Molecular Phenotype Improves Clinically Relevant Stratification of Head and Neck Cancer Patients. [PDF]

Cancers (Basel), 2022
Hess J, Unger K, Maihoefer C, Schüttrumpf L, Weber P, Marschner S, Wintergerst L, Pflugradt U, Baumeister P, Walch A, Woischke C, Kirchner T, Werner M, Sörensen K, Baumann M, Tinhofer I, Combs SE, Debus J, Schäfer H, Krause M, Linge A, von der Grün J, Stuschke M, Zips D, Canis M, Lauber K, Ganswindt U, Henke M, Zitzelsberger H, Belka C.   +29 more
europepmc   +1 more source