Results 81 to 90 of about 168,076 (265)

Research progress in the phytochemistry and biology of Ilex pharmaceutical resources

Acta Pharmaceutica Sinica B, 2013
Ilex is a botanical source for various health-promoting and pharmaceutically active compounds that have been used in traditional Chinese medicine and food for thousands of years.
Dacheng Hao, Xiaojie Gu, Peigen Xiao, Zhanguo Liang, Lijia Xu, Yong Peng   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Leveraging phytochemicals: the plant phylogeny predicts sources of novel antibacterial compounds

Future Science OA, 2019
Aim: The goal of this study was to use phylogenetic evidence to determine plant families with high representation of antibacterial activity and identify potential sources to focus on for antibacterial drug discovery. Materials & methods: We reconstructed
Malini A Prasad, Christine P Zolnik, Jeanmaire Molina   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The complete mitochondrial genome and phylogenetic analysis of Leptobotia bellacauda (Teleostei: Cypriniformes: Botiidae)

Mitochondrial DNA. Part B. Resources
The complete mitochondrial genome of Leptobotia bellacauda was sequenced and characterized for the first time. The mitogenome was a 16,591 bp circular molecule, including 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, two ribosomal RNA ...
YiJun Li, Xiaoge Yang, Mengqi Liao, Zhihua Zhong, Yuxi Lian   +4 more
doaj   +1 more source

Phylogenomics and barcoding of Panax: toward the identification of ginseng species

BMC Evolutionary Biology, 2018
Background The economic value of ginseng in the global medicinal plant trade is estimated to be in excess of US$2.1 billion. At the same time, the evolutionary placement of ginseng (Panax ginseng) and the complex evolutionary history of the genus is ...
V. Manzanilla, A. Kool, L. Nguyen Nhat, H. Nong Van, H. Le Thi Thu, H. J. de Boer   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Biogeographic history of the endangered dwarf buffalo, subgenus Anoa (Bovidae: Bubalus quarlesi and Bubalus depressicornis): a perspective based on mitochondrial DNA phylogeny [PDF]

Evolutionary Systematics
The Anoa, including the Mountain Anoa (Bubalus quarlesi) and the Lowland Anoa (Bubalus depressicornis) according to current taxonomy, are endangered bovid species endemic to the tropical island of Sulawesi.
Dwi Sendi Priyono, Dedy Duryadi Solihin, Achmad Farajallah, Bambang Purwantara   +3 more
doaj   +3 more sources