Results 41 to 50 of about 4,443,994 (251)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Salt Lake County Library System Historical Scrapbook, 1981-1982

, 1981
Salt Lake County Library System Historical ...
Salt Lake County (Utah). Library System
core   +1 more source

Crystal structure of 2-phenylethanaminium 3-carboxyprop-2-enoate

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title molecular salt, C8H12N+·C4H3O4−, crystallized with two independent cations and anions in the asymmetric unit. The ethanaminium side chains of the cations exhibit anti conformations [C—C—C—N torsion angles = 176.5 (3) and −179.4 (3)°].
N. Swarna Sowmya, S. Sampathkrishnan, R. Akilan, G. Chakkaravarthi, R. Mohan Kumar   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

2-Amino-4-methylpyridinium 2-hydroxybenzoate

IUCrData, 2016
The title molecular salt, C6H9N2+·C7H5O3−, contains two ion pairs in the asymmetric unit. Both anions feature an intramolecular O—H...O hydrogen bond, which closes an S(6) ring. In the crystal, N—H...O hydogen bonds link the components into [010] chains,
P. Sivakumar, S. Israel, G. Chakkaravarthi   +2 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

2-Amino-3-methylpyridinium hydrogen phthalate

IUCrData, 2017
In the title molecular salt, C6H9N2+·C8H5O4−, the cation is protonated at the pyridine N atom and the anion is deprotonated at the hydroxy O atom. The anion features an intramolecular O—H...O hydrogen bond with the H atom located almost in the middle of ...
P. Sivakumar, C. Anzline, S. Sudhahar, S. Israel, G. Chakkaravarthi   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Salt Lake County Library System Historical Scrapbook, 1980(b)

, 1980
Salt Lake County Library System Historical ...
Salt Lake County (Utah). Library System
core   +1 more source

New Miconazole Salts with Heterocyclic Carboxylic Acids with Improved Water Solubility and Enhanced Antifungal Activity

Molecules
Miconazole is a commonly used imidazole antifungal drug with a broad spectrum of activity against Candida strains and other microorganisms. However, its poor solubility and low bioavailability have limited its use to topical infections.
Anna Ben, Aleksandra Felczak, Michał Gacki, Katarzyna Lisowska, Mateusz Rafał Gołdyn, Elżbieta Bartoszak-Adamska, Lilianna Chęcińska   +6 more
doaj   +1 more source