Results 71 to 80 of about 1,132,343 (303)

2-Amino-4-methylpyridinium 2-hydroxybenzoate

IUCrData, 2016
The title molecular salt, C6H9N2+·C7H5O3−, contains two ion pairs in the asymmetric unit. Both anions feature an intramolecular O—H...O hydrogen bond, which closes an S(6) ring. In the crystal, N—H...O hydogen bonds link the components into [010] chains,
P. Sivakumar, S. Israel, G. Chakkaravarthi   +2 more
doaj   +1 more source

LXXXIV.—Molecular rotations of optically active salts [PDF]

J. Chem. Soc., Trans., 1897
n ...
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

2-Amino-3-methylpyridinium hydrogen phthalate

IUCrData, 2017
In the title molecular salt, C6H9N2+·C8H5O4−, the cation is protonated at the pyridine N atom and the anion is deprotonated at the hydroxy O atom. The anion features an intramolecular O—H...O hydrogen bond with the H atom located almost in the middle of ...
P. Sivakumar, C. Anzline, S. Sudhahar, S. Israel, G. Chakkaravarthi   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

PD-1 Bispecific Killer Engager (PD-1 BiKE) effectively depletes effector T lymphocytes in experimental autoimmune encephalomyelitis

Frontiers in Immunology
BackgroundBispecific killer engagers (BiKEs), which harness natural killer cells to deplete target cells, have garnered success in ablating tumor cells but have not been well explored in eliminating primary cells, such as effector cells in autoimmune ...
Lauren C. Naatz, Shuyun Dong, Yujia Zhai, Brian Evavold, Mingnan Chen   +4 more
doaj   +1 more source

Crystal structure of 4,4′-bipyridine-1,1'-diium naphthalene-2,6-disulfonate dihydrate

Acta Crystallographica Section E, 2014
The title hydrated molecular organic salt, C10H10N22+·C10H6O6S22−·2H2O, crystallized with half a bipyridinium cation, half a naphthalene-2,6-disulfonate anion and a water molecule in the asymmetric unit.
Sabri Çevik, Musa Sarı, Murat Sarı, Tuncay Tunç   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Steady-state ab initio laser theory for complex gain media

, 2014
We derive and test a generalization of Steady-State Ab Initio Laser Theory (SALT) to treat complex gain media. The generalized theory (C-SALT) is able to treat atomic and molecular gain media with diffusion and multiple lasing transitions, and ...
Cerjan, Alexander, Chong, Y. D., Stone, A. Douglas   +2 more
core   +1 more source

Salt Stress and Plant Molecular Responses

, 2022
Plants being sessile suffer from several abiotic stresses during growth. These include drought, salinity, heavy metal, temperature, and nutrient stress. Salt stress is one of the devastating abiotic stresses that plant suffers under natural growth conditions.
Usman Khalid Chaudhry, Zahide Neslihan Öztürk Gökçe, Ali Fuat Gökçe   +2 more
openaire   +2 more sources