Results 121 to 130 of about 19,554,258 (410)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Molecular structure of bottlebrush polymers in melts

Science Advances, 2016
Steric repulsion between grafted side chains inhibits interpenetration of bottlebrushes, transforming them into flexible filaments. Bottlebrushes are fascinating macromolecules that display an intriguing combination of molecular and particulate features ...
J. Paturej, S. Sheiko, Sergey Vladimir Panyukov, M. Rubinstein   +3 more
semanticscholar   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling

Journal of Lipid Research, 2009
Glucosamine impairs hepatic apolipoprotein B100 (apoB100) production by inducing endoplasmic reticulum (ER) stress and enhancing cotranslational and posttranslational apoB100 degradation (Qiu, W., R. K. Avramoglu, A. C. Rutledge, J. Tsai, and K.
Wei Qiu, Qiaozhu Su, Angela C. Rutledge, Jing Zhang, Khosrow Adeli   +4 more
doaj  

NONEXPERIMENTAL SCREENING OF THE WATER SOLUBILITY, LIPOPHILICITY, BIOAVAILABILITY, MUTAGENICITY AND TOXICITY OF VARIOUS PESTICIDES WITH QSAR MODELS AID [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2013
In our study the dataset containing 489 pesticides and their active substances of different classes of organic compounds was used for analysis. For compounds of analyzed dataset the values of lipophilicity, water solubility, toxicity, bioavailability and
O.G. Kolumbin, L.N. Ognichenko, A.G. Artemenko, P.G. Polischuk, М.A. Kulinsky, Е.N. Мuratov, V.E. Kuz’min, V.A. Bobeica   +7 more
doaj  

A method for detection of structure

, 2006
Context. In order to understand the evolution of molecular clouds it is important to identify the departures from self-similarity associated with the scales of self-gravity and the driving of turbulence. Aims.
Bally, Bensch, Blitz, Boldyrev, Chappell, Clénet, D. Field, Elmegreen, Falgarone, Farge, Gustafsson, Gustafsson, J. L. Lemaire, Kolmogorov, Kristensen, Kritsuk, Lacombe, Larson, M. Gustafsson, Mac Low, Ossenkopf, Padoan, Rouan, Stutzki, Stutzki, Vannier   +25 more
core   +3 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Spectroscopic-network-assisted precision spectroscopy and its application to water

Nature Communications, 2020
Precision-spectroscopy techniques can accurately measure lines in constrained frequency and intensity ranges. The authors propose a spectroscopic-network-assisted precision spectroscopy method by which transitions measured in a narrow range provide ...
Roland Tóbiás, Tibor Furtenbacher, Irén Simkó, Attila G. Császár, Meissa L. Diouf, Frank M. J. Cozijn, Joey M. A. Staa, Edcel J. Salumbides, Wim Ubachs   +8 more
doaj   +1 more source

Similarity Measure for Molecular Structure: A Brief Review

, 2017
Similarity or distance measures have been used widely to calculate the similarity or dissimilarity between two samples of dataset. Cheminformatics is known as the domain that dealing with chemical information and both similarity and distance coefficient ...
Siti Asmah Bero, A. Muda, Yun-Huoy Choo, N. A. Muda, Satrya Fajri Pratama   +4 more
semanticscholar   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source